A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation.
A neurobehavioral model of affiliative bonding: implications for conceptualizing a human trait of affiliation.
复制标题
DOI：
10.1017/s0140525x05000063
复制
发表时间：
2005-06
期刊：
影响因子：
--
通讯作者：
R. Depue;Jeannine Morrone-Strupinsky
中科院分区：
文献类型：
--
作者：
R. Depue;Jeannine Morrone-Strupinsky
由于对亲和性这一人格特质了解甚少，我们提出了一种新的亲和性联结的神经行为模型。讨论围绕亲和性的趋近和满足阶段所发生的奖赏及记忆形成过程展开。欲求性和满足性奖赏过程分别由腹侧被盖区（VTA）多巴胺（DA） - 伏隔核壳部（NAS）通路的活动以及内侧基底下丘脑弓状核的μ - 阿片系统的中央皮质边缘投射独立介导，尽管这两个投射系统在时间上存在功能交互。接下来我们阐述DA和谷氨酸在VTA和NAS中相互作用以形成激励编码的情境记忆集合的方式，这些集合可预测从亲和性对象获得的奖赏。特别是，亲和性刺激通过以下方式被纳入预测亲和性奖赏的情境集合中：（a）亲和性刺激在内侧扩展杏仁核的吻侧回路中结合，并随后传递至NAS壳部；（b）亲和性刺激诱导的VTA和NAS中DA过程的阿片增强作用；（c）性腺类固醇、催产素（与DA相互作用）和加压素对（i）亲和性刺激的感觉、知觉和注意力处理以及（ii）社会记忆形成的许可或促进作用。在这些不同的过程中，我们提出通过阿片功能体验亲和性奖赏的能力在决定亲和性的个体差异方面具有不成比例的重要性。我们描述了这些个体差异的来源，并提供了首批人类数据，支持阿片功能与特质亲和性的变异之间存在关联。
Because little is known about the human trait of affiliation, we provide a novel neurobehavioral model of affiliative bonding. Discussion is organized around processes of reward and memory formation that occur during approach and consummatory phases of affiliation. Appetitive and consummatory reward processes are mediated independently by the activity of the ventral tegmental area (VTA) dopamine (DA)-nucleus accumbens shell (NAS) pathway and the central corticolimbic projections of the u-opiate system of the medial basal arcuate nucleus, respectively, although these two projection systems functionally interact across time. We next explicate the manner in which DA and glutamate interact in both the VTA and NAS to form incentive-encoded contextual memory ensembles that are predictive of reward derived from affiliative objects. Affiliative stimuli, in particular, are incorporated within contextual ensembles predictive of affiliative reward via: (a) the binding of affiliative stimuli in the rostral circuit of the medial extended amygdala and subsequent transmission to the NAS shell; (b) affiliative stimulus-induced opiate potentiation of DA processes in the VTA and NAS; and (c) permissive or facilitatory effects of gonadal steroids, oxytocin (in interaction with DA), and vasopressin on (i) sensory, perceptual, and attentional processing of affiliative stimuli and (ii) formation of social memories. Among these various processes, we propose that the capacity to experience affiliative reward via opiate functioning has a disproportionate weight in determining individual differences in affiliation. We delineate sources of these individual differences, and provide the first human data that support an association between opiate functioning and variation in trait affiliation.