Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
Collagen type 3 alpha 1 polymorphism and risk of pelvic organ prolapse
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DOI：
10.1016/j.ijgo.2008.05.031
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发表时间：
2008-10-01
影响因子：
3.8
通讯作者：
Tsai, Chang-Hai
中科院分区：
文献类型：
--
作者：
Chen, Huey-Yi;Chung, Ya-Wen;Tsai, Chang-Hai
目的：探讨胶原蛋白3 α 1（COL 3A 1）基因多态性与盆腔器官脱垂（POP）的相关性。方法：采用病例对照研究方法，对84例POP患者和147例对照进行分析。应用聚合酶链反应-限制性片段长度多态性分析（PCR-RFLP）确定COL 3A 1 rs 1800255和COL 3A 1 rs 1801184多态性基因型。结果：COL 3A 1 rs 1800255基因型的分布在受影响的女性和对照组中存在显着差异。结论：COL 3A 1基因型可能与POP的发病风险有关。（c）2008年国际妇产科联合会（International Federation of Gynecology and Obstetrics）。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: To investigate whether pelvic organ prolapse (POP) is associated with collogen 3 alpha 1 (COL3A1) polymorphisms and other factors. Methods: A case-control association study was conducted with 84 women affected with POP and 147 controls. The genotypes of nucleotides COL3A1 rs1800255 and COL3A1 rs1801184 polymorphisms were ascertained by polymerase chain reaction and restriction fragment length polymorphism analysis. Results: The distribution of the COL3A1 rs1800255 genotypes was significantly different among affected women and controls. Older age and incidence of COL3A1 rs1800255 genotype AA were significantly associated with risk of POP. Conclusion: There may be an association between COL3A1 genotype and risk of POP. (c) 2008 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.