No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
No association between the metabotropic glutamate receptor type 3 gene (GRM3) and schizophrenia in a Japanese population
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DOI：
10.1016/j.schres.2006.07.008
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发表时间：
2006-12
影响因子：
4.5
通讯作者：
Mamoru Tochigi;M. Suga;J. Ohashi;Takeshi Otowa;H. Yamasue;K. Kasai;Tadafumi Kato;Y. Okazaki;Nobumasa Kato;Tsukasa Sasaki
中科院分区：
文献类型：
--
作者：
Mamoru Tochigi;M. Suga;J. Ohashi;Takeshi Otowa;H. Yamasue;K. Kasai;Tadafumi Kato;Y. Okazaki;Nobumasa Kato;Tsukasa Sasaki
多项证据表明代谢型谷氨酸受体 3 (GRM3) 基因是精神分裂症的候选易感基因。据我们所知，有六项研究调查了 GRM3 与精神分裂症之间的遗传关联，尽管结果颇有争议。在本研究中，我们通过分析 10 个单核苷酸多态性 (SNP)，包括之前研究中显示出显着结果的所有 SNP，调查了 402 名日本人的 GRM3 基因与精神分裂症之间的关联。我们观察到对照组和患者之间 10 个 SNP 的等位基因频率或基因型分布没有显着差异。排列测试显示对照组和患者之间估计的单倍型频率没有显着的总体差异。因此，本研究没有提供GRM3基因与日本人群精神分裂症之间关联的积极证据。
Several lines of evidence have suggested that the metabotropic glutamate receptor 3 (GRM3) gene is a candidate susceptibility gene for schizophrenia. To our knowledge, six studies have investigated the genetic association between GRM3 and schizophrenia, although the results have been quite controversial. In the present study, we investigated the association between the GRM3 gene and schizophrenia in 402 Japanese people by analyzing 10 single nucleotide polymorphisms (SNPs), including all SNPs that showed significant results in previous studies. We observed no significant difference in allelic frequencies or genotypic distributions of the 10 SNPs between the controls and patients. A permutation test showed no significant global differences in estimated haplotype frequencies between the controls and patients. Thus, the present study provides no positive evidence of an association between the GRM3 gene and schizophrenia in the Japanese population.