Regeneration potential of decellularized periodontal ligament cell sheets combined with 15-deoxy-Δ12,14-prostaglandin J2 nanoparticles in a rat periodontal defect
Regeneration potential of decellularized periodontal ligament cell sheets combined with 15-deoxy-Δ12,14-prostaglandin J2 nanoparticles in a rat periodontal defect
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脱细胞牙周膜细胞片联合15-脱氧-Delta(12,14)-前列腺素J(2)纳米粒子在大鼠牙周缺损中的再生潜力
DOI：
10.1088/1748-605x/abee61
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发表时间：
2021-07-01
影响因子：
4
通讯作者：
Wu，Yan-Min
中科院分区：
文献类型：
--
作者：
Jiang，Yao;Liu，Jia-Mei;Wu，Yan-Min
牙周炎是一种慢性炎症性疾病，其特征是牙周组织的附着丧失和破坏。脱细胞膜作为一种先进的组织再生工程生物材料，已在多个领域得到研究和应用，但其对牙周组织再生的影响尚不清楚。本研究对脱细胞人牙周膜细胞（dHPDLC）片的生物学特性进行了体外评价。制备了聚己内酯/明胶（PCL/GE）纳米纤维作为载体以提高dHPDLC片材的机械强度。15-脱氧-
Periodontitis is a chronic inflammatory disease characterized by loss of attachment and destruction of the periodontium. Decellularized sheet, as an advanced tissue regeneration engineering biomaterial, has been researched and applied in many fields, but its effects on periodontal regeneration remain unclear. In this study, the biological properties of decellularized human periodontal ligament cell (dHPDLC) sheets were evaluated in vitro. Polycaprolactone/gelatin (PCL/GE) nanofibers were fabricated as a carrier to enhance the mechanical strength of the dHPDLC sheet. 15-deoxy-