High serum concentration of vitamin D may protect against multiple sclerosis
High serum concentration of vitamin D may protect against multiple sclerosis
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DOI：
10.1177/2055217319892291
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发表时间：
2019-10-01
影响因子：
2.8
通讯作者：
Sundstrom, Peter
中科院分区：
文献类型：
--
作者：
Bistrom, Martin;Alonso-Magdalena, Lucia;Sundstrom, Peter
背景资料：高浓度的25-羟基维生素D与多发性硬化症的风险降低有关，在年轻人中有更强的效果。目的：调查25-羟基维生素D与多发性硬化症的关系，并测试这种关系是否与年龄有关。普罗维登斯从后来发展为复发缓解型多发性硬化症的个体和与生物库、性别、结果：高水平的25-羟基维生素D（最高五分位数）与多发性硬化风险降低相关（优势比0.68，95%可信区间0.50-0.93）。结论：这些发现进一步支持维生素D在MS病因学中的作用。
Background: High 25-hydroxyvitamin D concentrations have been associated with a reduced risk of multiple sclerosis, with indications of a stronger effect among young individuals.Objective: Investigate the 25-hydroxyvitamin D association with multiple sclerosis and test if this association is age dependent.Methods: Prospectively drawn blood samples from individuals later developing relapsing-remitting multiple sclerosis and controls matched for biobank, sex, age and date of sampling, were analysed with liquid chromatography tandem mass spectrometry.Results: High levels of 25-hydroxyvitamin D (top quintile) were associated with a reduced multiple sclerosis risk (odds ratio 0.68, 95% confidence interval 0.50-0.93).Conclusion: These findings further support a role for vitamin D in MS aetiology.