Vascular Effects on Cerebrovascular Permeability and Neurodegeneration.
Vascular Effects on Cerebrovascular Permeability and Neurodegeneration.
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DOI：
10.3390/biom13040648
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发表时间：
2023-04-04
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
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脑中的神经元和神经胶质细胞受到血脑屏障（BBB）的保护。血流的局部调节由神经元和称为星形胶质细胞的信号传导细胞决定。虽然神经元和神经胶质细胞的改变会影响神经元的功能，但大多数影响来自身体的其他细胞和器官。虽然似乎显而易见的是，在脑血管系统中开始的影响将在各种神经炎症和神经退行性病变的发展中发挥重要作用，但在过去十年中，人们只对血管性认知障碍和痴呆（VCID）发展中涉及的可能机制产生了重大兴趣。目前，国家神经疾病和中风研究所对阿尔茨海默病期间VCID和血管损伤相关的研究给予了相当大的关注。因此，脑血管的任何变化，如血流、血栓形成、渗透性或其他影响血管-神经元连接和相互作用并导致神经元变性导致记忆力下降的变化，应被视为VCID类别下的研究对象。在几种可能引发神经退行性变的血管效应中，脑血管通透性的变化似乎导致了最具破坏性的效应。本综述强调了血脑屏障变化的重要性和可能的机制，主要涉及纤维蛋白原在神经炎症和神经退行性疾病的发展和/或进展，导致记忆力下降。
Neurons and glial cells in the brain are protected by the blood brain barrier (BBB). The local regulation of blood flow is determined by neurons and signal conducting cells called astrocytes. Although alterations in neurons and glial cells affect the function of neurons, the majority of effects are coming from other cells and organs of the body. Although it seems obvious that effects beginning in brain vasculature would play an important role in the development of various neuroinflammatory and neurodegenerative pathologies, significant interest has only been directed to the possible mechanisms involved in the development of vascular cognitive impairment and dementia (VCID) for the last decade. Presently, the National Institute of Neurological Disorders and Stroke applies considerable attention toward research related to VCID and vascular impairments during Alzheimer’s disease. Thus, any changes in cerebral vessels, such as in blood flow, thrombogenesis, permeability, or others, which affect the proper vasculo-neuronal connection and interaction and result in neuronal degeneration that leads to memory decline should be considered as a subject of investigation under the VCID category. Out of several vascular effects that can trigger neurodegeneration, changes in cerebrovascular permeability seem to result in the most devastating effects. The present review emphasizes the importance of changes in the BBB and possible mechanisms primarily involving fibrinogen in the development and/or progression of neuroinflammatory and neurodegenerative diseases resulting in memory decline.
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影响因子：
16.2
作者：
Cortes-Canteli, Marta;Paul, Justin;Norris, Erin H.;Bronstein, Robert;Ahn, Hyung Jin;Zamolodchikov, Daria;Bhuvanendran, Shivaprasad;Fenz, Katherine M.;Strickland, Sidney
通讯作者：
Strickland, Sidney
影响因子：
8.3
作者：
del Zoppo GJ;Levy DE;Wasiewski WW;Pancioli AM;Demchuk AM;Trammel J;Demaerschalk BM;Kaste M;Albers GW;Ringelstein EB
通讯作者：
Ringelstein EB
影响因子：
2.5
作者：
Charkviani, Mariam;Muradashvili, Nino;Lominadze, David
通讯作者：
Lominadze, David
影响因子：
82.9
作者：
Deane, R;Yan, SD;Zlokovic, B
通讯作者：
Zlokovic, B
影响因子：
48
作者：
Benedict, Ralph H. B.;Amato, Maria Pia;DeLuca, John;Geurt, Jeroen J. G.
通讯作者：
Geurt, Jeroen J. G.