Synthesis and characterization of thermoresponsive polymers containing reduction-sensitive disulfide linkage
Synthesis and characterization of thermoresponsive polymers containing reduction-sensitive disulfide linkage
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DOI：
10.1002/pola.23642
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发表时间：
2009-11
期刊：
影响因子：
--
通讯作者：
Lihua Li;Xulin Jiang;R. Zhuo
中科院分区：
文献类型：
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作者：
Lihua Li;Xulin Jiang;R. Zhuo
合成了一类新型的热敏性和还原敏感型聚合物p(PEG-MEMA-co-Boc-cyst-MMAm)，该聚合物含有二硫键和可移除的疏水叔丁氧羰基侧链。用UV/Vis光谱仪测得p(PEGMEMA-co-Boc-cyst-MMAm)在水中的浊点(Cp)在20℃到57℃之间，这表明可以通过调节共聚物的组成来调节Cp。此外，热敏聚合物p(PEG-MEMA-co-Boc-cyst-MMAm)在中性水介质中形成稳定的纳米粒子，但在模拟细胞内空间的还原环境中迅速失稳，使其适合于细胞质药物输送。©2009威利期刊公司J Polym Sci Part A：Polym Chem 47：5989-5997,2009
A novel class of thermoresponsive and reduction-sensitive polymer, p(PEG-MEMA-co-Boc-Cyst-MMAm), containing disulfide linkages and removable hydrophobic tert-butyloxycarbonyl side chains was synthesized. The cloud points (CP) of p(PEG-MEMA-co-Boc-Cyst-MMAm) in water determined by UV/VIS spectrometer were between 20 °C and 57 °C, which shows that the CP can be tuned by adjusting the copolymer composition. Moreover, the thermosensitive polymers p(PEG-MEMA-co-Boc-Cyst-MMAm) formed stable nanoparticles in neutral aqueous medium, but rapidly destabilized in an reductive environment mimicking the intracellular space making them suitable for cytoplasmic drug delivery. © 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 5989–5997, 2009