Low zinc levels may contribute to gynecomastia in puberty
Low zinc levels may contribute to gynecomastia in puberty
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DOI：
10.1016/j.jtemb.2017.09.001
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发表时间：
2017-01-01
影响因子：
3.5
通讯作者：
Kocer-Gumusel, Belma
中科院分区：
文献类型：
--
作者：
Erkekoglu, Pinar;Durmaz, Erdem;Kocer-Gumusel, Belma
本研究旨在确定青春期男性乳房发育症男孩与正常男孩之间微量元素水平是否存在差异，并确定微量元素水平与身体质量指数（BMI）和性激素之间的相关性。青春期男性乳房发育症组包括41例患者（平均年龄= 13.2±0.9岁），他们被安卡拉Hacettepe大学ihsan Dogramaci儿童医院收治。对照组为21名健康男性儿童。微量元素含量分析采用原子吸收光谱法。对照组平均锌水平为101.33 +/- 16.87 mu g/dL，男性乳房发育症组平均锌水平为81.36 +/- 17.43 mu g/dL（男性乳房发育症患者低20%，p = 0.0001）。然而，男性乳房发育症患者的平均铜和锰水平与对照组没有统计学差异。男性乳房发育症组血浆锌与总睾酮水平呈显著正相关（r = 0.592; p < 0.05）。血浆锌水平与BMI呈显著负相关（r = 0.311; p < 0.05）。这些结果提示，锌缺乏可能是男性乳房发育的潜在因素之一，其重要性有待进一步阐明。
This study aimed to determine whether there were any differences in trace element levels between adolescent boys with gynecomastia and control boys and to determine the correlations between the levels of trace elements and body mass index (BMI) and sex hormones. The pubertal gynecomastia group comprised of 41 patients (mean age = 13.2 +/- 0.9 years), who were admitted to Hacettepe University ihsan Dogramaci Children's Hospital in Ankara. Control group comprised of 21 healthy male children. Analyses of trace element levels were performed atomic absorption spectrometry. The mean zinc level of control group was 101.33 +/- 16.87 mu g/dL and the mean zinc level of gynecomastia group was 81.36 +/- 17,43 mu g/dL (20% lower in gynecomastia patients, p = 0.0001). However, the mean copper and manganese levels of gynecomastia patients were not statistically different than the control group. There were significant positive correlations between plasma zinc and total testosterone levels in gynecomastia group (r = 0.592; p < 0.05). There was a significant negative correlation between plasma zinc levels and BMI (r = 0.311; p < 0.05). These results indicate that zinc deficiency might be one of the underlying factors of gynecomastia, the importance of which needs to be further elucidated.