LOCAL RULE-BASED THEORY OF VIRUS SHELL ASSEMBLY
LOCAL RULE-BASED THEORY OF VIRUS SHELL ASSEMBLY
复制标题
DOI：
10.1073/pnas.91.16.7732
复制
发表时间：
1994-08-02
影响因子：
11.1
通讯作者：
KING, J
中科院分区：
文献类型：
--
作者：
BERGER, B;SHOR, PW;KING, J
发展了一个基于局部规则的理论，该理论表明二十面体病毒壳的自组装可能仅依赖于蛋白质亚基与其邻居的低水平相互作用，而不是更大的结构构建块。局部规则理论为理解二十面体病毒的组装提供了一个框架，这些病毒包括属于Caspar和Klug的准等价理论的病毒和多瘤病毒结构，多瘤病毒结构违反了准等价理论，并且自从它第一次被观察以来就一直困扰着研究人员。地方规则本质上是积极有利安排的模板。这些规则的公差范围进行了研究，通过计算机模拟。当以特定方式超过这些公差范围时，结果是在自然界中观察到的“螺旋形”畸形。
A local rule-based theory is developed which shows that the self-assembly of icosahedral virus shells may depend on only the lower-level interactions of a protein subunit with its neighbors-i.e., on local rules rather than on larger structural building blocks. The local rule theory provides a framework for understanding the assembly of icosahedral viruses, These include both viruses that fall in the quasi-equivalence theory of Caspar and Klug and the polyoma virus structure, which violates quasi-equivalence and has puzzled researchers since it was first observed. Local rules are essentially templates for energetically favorable arrangements. The tolerance margins for these rules are investigated through computer simulations. When these tolerance margins are exceeded in a particular way, the result is a ''spiraling'' malformation that has been observed in nature.