Functional sites in the laminin alpha chains
Functional sites in the laminin alpha chains
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DOI：
10.1080/03008200591008527
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发表时间：
2005-01-01
影响因子：
2.9
通讯作者：
Nomizu, M
中科院分区：
文献类型：
--
作者：
Suzuki, N;Yokoyama, F;Nomizu, M
层粘连蛋白是由α、β和伽马链组成的杂三聚体，是存在于基底膜上的多功能糖蛋白。层粘连蛋白是发育早期基底膜组装过程中最重要的基底膜成分，参与细胞黏附、迁移、生长、分化、肿瘤转移和血管生成等多种生物学活动。总共有15种层粘连蛋白亚型已经被鉴定出来，并且是组织和/或发育阶段特异表达的。整合素、营养不良多糖、合成酶和其他几种细胞表面分子是层粘连蛋白的细胞受体。位于层粘连蛋白α链N端和C端的球状结构域对于与细胞受体的相互作用是至关重要的。层粘连蛋白a链之间存在高度保守的功能位点和链特异的功能位点。此外，层粘连蛋白由特定的内源性酶处理，该处理调节层粘连蛋白的功能。层粘连蛋白中的功能序列与细胞受体结合，触发细胞内信号传递，继而诱导包括细胞扩散和迁移在内的各种细胞活动。层粘连蛋白具有多功能序列，是决定细胞命运的关键分子。
Laminins, heterotrimers composed of a, beta, and gamma chains, are multifunctional glycoproteins present in basement membranes. Laminins, the most important component of basement membranes during basement membrane assembly in early development, are involved in various biological activities such as cell adhesion, migration, growth, differentiation, tumor metastasis, and angiogenesis. Fully 15 laminin isoforms have been identified and are tissue- and/or developmental stage-specifically expressed. Integrins, dystroglycan, syndecans, and the other several cell surface molecules are cellular receptors for laminins. The globular domains located in the N- and C-terminus of the laminin alpha chains are critical for interactions with the cellular receptors. There are highly conserved functional sites and chain-specific functional sites among the laminin a chains. Additionally, laminins are processed by specific endogenous proteases and the processing regulates laminin functions. Binding of the functional sequences in laminins to the cellular receptors triggers intracellular signaling, followed by inducing various cell activities including cell spreading and migration. Laminins possess multifunctional sequences and are key molecules that determine cell fate.