Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76
Coordination of Receptor Signaling in Multiple Hematopoietic Cell Lineages by the Adaptor Protein SLP-76
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DOI：
10.1101/cshperspect.a002501
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发表时间：
2010-04-01
影响因子：
7.2
通讯作者：
Koretzky, Gary A.
中科院分区：
文献类型：
--
作者：
Jordan, Martha S.;Koretzky, Gary A.
适配蛋白SLP-76在多种造血谱系中表达，包括T细胞、血小板和中性粒细胞。SLP-76介导的信号依赖于它的多个蛋白质相互作用域，因为它创建了一个支架，在这个支架上构建了关键的信号复合物。SLP-76对于支持免疫受体和整合素的下游信号传导至关重要。SLP-76的上游和下游所使用的信号分子在这些受体和不同细胞类型之间是相似的；然而，存在着重要的差异。了解SLP-76如何协调不同细胞和受体类型之间的信号转导，可以深入了解对宿主防御至关重要的免疫系统细胞激活至关重要的途径的复杂相互作用。
The adaptor protein SLP-76 is expressed in multiple hematopoietic lineages including T cells, platelets, and neutrophils. SLP-76 mediated signaling is dependent on its multiple protein interaction domains, as it creates a scaffold on which key signaling complexes are built. SLP-76 is critical for supporting signaling downstream of both immunoreceptors and integrins. The signaling molecules used both upstream and downstream of SLP-76 are similar among these receptors and across cell types; however, important differences exist. Appreciating how SLP-76 coordinates signal transduction across different cell and receptor types provides insights into the complex interplay of pathways critical for activation of cells of the immune system that are essential for host defense.