A direct demonstration of cortical UP in humans: A combined TMS/EEG study
A direct demonstration of cortical UP in humans: A combined TMS/EEG study
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DOI：
10.1016/j.brainresbull.2005.11.003
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发表时间：
2006-03-15
影响因子：
3.8
通讯作者：
Tononi, G
中科院分区：
文献类型：
--
作者：
Esser, SK;Huber, R;Tononi, G
重复经颅磁刺激（rTMS）越来越多地用于促进皮质重组，假设它可以诱导神经反应的长时程增强（LTP）。这一假设得到了若干间接证据的支持。例如，运动皮层的rTMS可以诱导肌肉运动诱发电位的增强，其持续时间比刺激长几分钟。在动物模型中，LTP的直接证明通常通过高频电刺激结合群体反应的局部场记录来获得。在这项研究中，我们开发了一种新的方法，结合rTMS/高密度脑电图（HD-EEG），以获得直接的，非侵入性的证据，在人类的LTP。在对运动皮质施加rTMS（5 Hz，1500个脉冲）之前和之后，使用hd-EEG测量对单个TMS脉冲的皮质反应。结果表明，rTMS后，EEG反应在15-55 ms的潜伏期显着增强。地形分析表明，这种增强是显着的EEG电极位于两侧运动前皮层。因此，这些发现提供了rTMS诱导的人类LTP的直接证明。(c)2005年爱思唯尔公司All rights reserved.
Repetitive transcranial magnetic stimulation (rTMS) is increasingly being used to promote cortical reorganization, under the assumption that it can induce long-term potentiation (LTP) of neural responses. This assumption is supported by several lines of indirect evidence. For example, rTMS of motor cortex can induce a potentiation of muscle motor evoked potentials that outlasts the stimulation by several minutes. In animal models, a direct demonstration of LTP is typically obtained by high-frequency electrical stimulation coupled with local field recordings of population responses. In this study, we exploited a new approach based on combined rTMS/high-density electroencephalography (hd-EEG) to obtain direct, noninvasive evidence for LTP in humans. Cortical responses to single TMS pulses were measured with hd-EEG before and after applying rTMS to motor cortex (5 Hz, 1500 pulses). The results demonstrate that, after rTMS, EEG responses at latencies of 15-55 ms were significantly potentiated. A topographic analysis revealed that this potentiation was significant at EEG electrodes located bilaterally over premotor cortex. Thus, these findings provide a direct demonstration in humans of LTP induced by rTMS. (c) 2005 Elsevier Inc. All rights reserved.