THE DEXAMETHASONE SUPPRESSION TEST IN CHILDREN AND ADOLESCENTS - A REVIEW AND A CONTROLLED-STUDY
THE DEXAMETHASONE SUPPRESSION TEST IN CHILDREN AND ADOLESCENTS - A REVIEW AND A CONTROLLED-STUDY
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DOI：
10.1016/0006-3223(92)90015-r
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发表时间：
1992-07-15
影响因子：
10.6
通讯作者：
PUIGANTICH, J
中科院分区：
文献类型：
--
作者：
DAHL, RE;KAUFMAN, J;PUIGANTICH, J
地塞米松抑制试验（DST）在儿童和青少年进行的研究进行审查，连同假设的因素来解释的DST非抑制率的研究之间的差异。这些因素，然后检查在27例青少年抑郁症（MDD）和34名正常对照（NC）的对照研究。受试者在11：00 PM给予1 mg地塞米松，第二天从8 AM至11 PM通过留置导管每小时采集皮质醇血清样品。MDD和NC受试者在任何地塞米松后皮质醇测量方面均无显著差异。此外，皮质醇抑制剂和非抑制剂没有通过从综述中确定的任何假设因素来区分，包括住院状态、自杀倾向的存在、内源性特征、精神病症状或MDD既往史。地塞米松的1毫克剂量（目前用于青少年的标准剂量）的适当性的问题提出，连同压力对DST结果的影响的讨论。
Dexamethasone Suppression Test (DST) studies conducted in children and adolescents are reviewed, together with factors hypothesized to explain discrepancies in rates of DST nonsuppression across studies. These factors are then examined in a controlled study of 27 adolescents with major depressive disorder (MDD) and 34 normal controls (NC). Subjects were given 1 mg of dexamethasone at 11:00 PM, and the following day serum samples for cortisol were collected each hr from 8 AM to 11 PM through an indwelling catheter. There were no significant differences found between the MDD and NC subjects on any postdexamethasone cortisol measure. Further, cortisol suppressors and nonsuppressors were not distinguished by any of the hypothesized factors identified from the review, including inpatient status, presence of suicidality, endogenous features, psychotic symptoms, or prior history of MDD. Questions about the appropriateness of the 1 mg dose of dexamethasone (currently the standard dose used with adolescents) are raised, together with a discussion of the effects of stress on DST findings.