Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air.
Application of copper(II)-dipyridylphosphine catalyst in the asymmetric hydrosilylation of simple ketones in air.
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DOI：
10.1002/chem.200900499
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发表时间：
2009-06
期刊：
影响因子：
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通讯作者：
Xi‐Chang Zhang;Yan Wu;F. Yu;Feifei Wu;Jing Wu;A. Chan
中科院分区：
文献类型：
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作者：
Xi‐Chang Zhang;Yan Wu;F. Yu;Feifei Wu;Jing Wu;A. Chan
铜：铜（II）盐/手性二吡啶膦/PhSiH(3)体系（见图）作为一种非常有效和实用的催化剂，在空气中不对称还原杂芳烃和其他类型的酮，具有良好到优异的对映选择性（高达94%），产生许多手性醇，这些手性醇是生理活性化合物的中间体。一些杂芳香酮类化合物的温度效应显著。
Ask a copper: A copper(II) salt/chiral dipyridylphosphine/PhSiH(3) system (see scheme) acts as a very effective and practical catalyst for the asymmetric reduction of heteroaromatic and other types of ketones in air with good-to-excellent enantioselectivities (up to 94%), giving many chiral alcohols that are intermediates for physiologically active compounds. Remarkable temperature effects were observed for some heteroaromatic ketones.