AN EFFICIENT AND SELECTIVE METHOD FOR THE PREPARATION OF IODOPHENOLS
AN EFFICIENT AND SELECTIVE METHOD FOR THE PREPARATION OF IODOPHENOLS
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DOI：
10.1021/jo00305a026
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发表时间：
1990-08-31
影响因子：
3.6
通讯作者：
FALLING, SN
中科院分区：
文献类型：
--
作者：
EDGAR, KJ;FALLING, SN
用次氯酸钠和碘化钠原位取代的试剂，在醇水溶液中，可实现多种酚类化合物的直接碘化，其选择性是前所未有的。通过简单的分离技术以相当高的产率获得对位取代的酚（或邻位取代的，当对位已经被占据时）。碘化的程度很容易通过化学计量控制。该技术也适用于一些苯胺。
Direct iodination of a wide range of phenols may be achieved with unprecedented selectivity in aqueous alcohol solvents by the action of a reagent preparated in situ from sodium hypochlorite and sodium iodidle. Para-substituted phenols (or ortho-substituted, when the para-position is already occupied) are obtained in fair to excellent yields by simple isolation techniques. The extent of iodination is easily controlled by stoichiometry. The technique is also useful with some anilines.