Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development.
Roles of Long Non-Coding RNAs on Tumorigenesis and Glioma Development.
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长期非编码RNA在肿瘤发生和神经胶质瘤发育中的作用。
DOI：
10.14791/btrt.2014.2.1.1
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发表时间：
2014-04
期刊：
影响因子：
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通讯作者：
Kim JH
中科院分区：
文献类型：
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作者：
Park JY;Lee JE;Park JB;Yoo H;Lee SH;Kim JH
超过98%的真核生物转录组是由没有功能性蛋白质编码能力的非编码rna组成的。这些转录本还包括成千上万的长链非编码rna (lncrna)，它们是细胞稳态的关键要素，本质上是肿瘤发生的步骤。然而，我们才刚刚开始了解lncrna参与肿瘤发生的性质和程度。在这里，我们重点介绍了最近的研究进展，包括转移相关肺腺癌转录物1 （MALAT1）、前列腺癌相关非编码RNA 1 （PRNCR1）、前列腺癌基因表达标记物1 （PCGEM1）、H19和同源盒转录反义基因间RNA （HOTAIR）等lncRNAs在肿瘤发生中的无数分子功能，以及一些与胶质瘤发展有关的新lncRNAs。还讨论了lncrna在各种人类疾病中的潜在治疗方法。
More than 98% of eukaryotic transcriptomes are composed of non-coding RNAs with no functional protein-coding capacity. Those transcripts also include tens of thousands of long non-coding RNAs (lncRNAs) which are emerging as key elements of cellular homeostasis, essentially tumorigenesis steps. However, we are only beginning to understand the nature and extent of the involvement of lncRNAs on tumorigeneis. Here, we highlight recent progresses that have identified a myriad of molecular functions on tumorigenesis for several lncRNAs including metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), prostate cancer associated non-coding RNA 1 (PRNCR1), prostate cancer gene expression marker 1 (PCGEM1), H19, and homeobox transcript antisense intergenic RNA (HOTAIR), and several new lncRNAs for glioma development. Potential therapeutic approaches for the lncRNAs in various human diseases are also discussed.