Heparin and Related Polysaccharides
Heparin and Related Polysaccharides
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肝素及相关多糖
DOI：
--
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发表时间：
1992
影响因子：
--
通讯作者：
Related Polysaccharides
中科院分区：
文献类型：
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作者：
D. Lane;I. Björk;U. Lindahl;Related Polysaccharides
历史方面-肝素简介肝素和硫酸乙酰肝素的结构特性。糖胺聚糖领域的化学合成和半合成。高碘酸氧化肝素的结构分析肝素结构分析和低分子量肝素生产的新方法。硫酸乙酰肝素蛋白聚糖：膜相关物种的分子组织和多糖序列分析方法。肝素和硫酸乙酰肝素蛋白多糖细胞方面。编码肝素蛋白聚糖和储存在造血细胞分泌颗粒中的其他蛋白聚糖的肽核心的基因的调节。硫酸乙酰肝素蛋白聚糖的结构和功能多样性。Syndecan-ACell表面蛋白聚糖，选择性结合细胞外效应分子。硫酸乙酰肝素蛋白聚糖和细胞粘附中的信号传导。肝素和硫酸乙酰肝素蛋白聚糖的相互作用和代谢。硫酸乙酰肝素聚合缺陷的动物细胞突变体。二合一酶：肝素生物合成中的N-脱乙酰化和N-硫酸化由同一蛋白质催化。血浆膜相关硫酸乙酰肝素蛋白聚糖的代谢肝素和硫酸乙酰肝素的溶酶体降解。[A103，106，108] Antristasin 93-119的羧基末端结构域的肝素结合特性。肝素蛋白质相互作用。抗凝血蛋白质。蛋白质构象变化、表面近似和蛋白质辅因子在肝素加速的抗凝血酶-脯氨酸酶反应中的作用糖胺聚糖与肝素辅因子II的相互作用：高亲和力硫酸皮肤素六聚糖的结构和活性。血栓调节蛋白：具有生理相关糖胺聚糖部分的抗凝血细胞表面蛋白聚糖。LACI和肝素之间的相互作用。组织通路抑制剂和肝素。抗血栓机制。低分子量肝素：抗血栓形成和抗凝作用之间的关系。肝素在体外和体内的作用模式。预防有效剂量的依诺肝素和肝素抑制凝血酶原激活。临床应用-肝素和硫酸地马坦的药代动力学：临床意义。肝素在预防和治疗动脉血栓栓塞中的作用。糖胺聚糖在静脉血栓栓塞预防中的作用用低分子量肝素（LMWH）治疗深静脉血栓形成（DVT）。肝素的剂量、抗凝作用与临床疗效和安全性的关系新视角。肝素和硫酸乙酰肝素对蛋白酶Nexin-1活性的调节定义硫酸乙酰肝素链的序列特异性合成的新方法。肝素对新生血管形成和转移种类的调节肝素及其衍生物的抗炎作用：抑制补体和淋巴细胞迁移。硫酸乙酰肝素糖胺聚糖作为单纯疱疹病毒的主要细胞表面受体。肝素和其他硫酸多糖对血管生成的控制。
Historical Aspects.- Heparin-An Introduction.- Structural Properties of Heparin and Heparan Sulphate.- Chemical Synthesis and Hemisynthesis in the Field of Glycosaminoglycans.- Structural Analysis of Periodate-Oxidized Heparin.- New Methodologies in Heparin Structure Analysis and the Generation of LMW Heparins.- Heparan Sulphate Proteoglycans: Molecular Organisation of Membrane-Associated Species and an Approach to Polysaccharide Sequence Analysis.- Heparin and Heparan Sulphate Proteoglycanscellular Aspects.- Regulation of the Gene that Encodes the Peptide Core of Heparin Proteoglycan and Other Proteoglycans that are Stored in the Secretory Granules of Hematopoietic Cells.- Structural and Functional Diversity of the Heparan Sulphate Proteoglycans.- Syndecan-ACell Surface Proteoglycan that Selectively Binds Extracellular Effector Molecules.- Heparan Sulphate Proteoglycans and Signalling in Cell Adhesion.- Heparin and Heparan Sulphate Proteoglycansinteractions and Metabolism.- Animal Cell Mutants Defective in Heparan Sulphate Polymerization.- Two Enzymes in One: N-Deacetyation and N-Sulpfation in Heparin Biosynthesis are Catalyzed by the Same Protein.- Metabolism of Plasma Membrane-Associated Heparan Sulphate Proteoglycans.- Lysosomal Degradation of Heparin and Heparan Sulphate.- Heparin Binding Properties of the Carboxyl Terminal Domain of [A103,106,108] Antristasin 93-119.- Heparin Protein Interactions.- Anticoagulant Proteins.- Role of Protein Conformational Changes, Surface Approximation, and Protein Cofactors in Heparin-Accelerated Antithrombin-Proeinase Reations.- The Interaction of Glycosaminoglycans with Heparin Cofactor II: Structure and Activity of a High-Affinity Dermatan Sulphate Hexasaccharide.- Thrombomodulin: An Anticoagulant Cell Surface Proteoglycan With Physiologically Relevant Glycosaminoglycan Moiety.- The Interaction Between LACI and Heparin.- Tissue Pathway Inhibitor and Heparin.- Antithrombotic Mechanisms.- LMW Heparin: Relationship Between Antithrombotic and Anticoagulant Effects.- The Mode of Action of Heparins In Vitro and In Vivo.- Prophylactically Effective Doses of Enoxaparin and Heparin Inhibit Prothrombin Activation.- Clinical Use.- Pharmacokinetics of Heparin and of Dematan Sulphate: Clinical Implications.- Heparin in the Prevention and Treatment of Arterial Thromboembolism.- Glycosaminoglycans in the Prophylaxis Against Venous Thromboembolism.- Treatment of Deep Vein Thrombosis (DVT) with Low Molecular Weight Heparin (LMWH).- Relationship Between Dose, Anticoagulant Effect and the Clinical Efficacy and Safety of Heparin.- New Perspectives.- Regulation of Protease Nexin-1 Activity by Heparin and Heparan Sulphate.- New Approaches for Defining Sequence Specific Synthesis of Heparan Sulphate Chains.- Modulation of Neovascularization and Metastasis Species of Heparin.- Anti-inflammatory Effects of Heparin and its Derivatives: Inhibition of Complement and of Lymphocyte Migration.- Heparan Sulphate Glycosaminoglycans as Primary Cell Surface Receptors for Herkpes Simplex Virus.- Control of Angiogenesis by Heparin and Other Sulphated Polysaccharides.
DOI：
10.1016/s0021-9258(18)38125-0
发表时间：
1991-04
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
S. Olson;I. Björk
通讯作者：
S. Olson;I. Björk
C1抑制剂Ma的底物性质（丙氨酸434----谷氨酸）。
DOI：
--
发表时间：
1991
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Skriver,K;Wikoff,WR;Patston,PA;Tausk,F;Schapira,M;Kaplan,AP;Bock,SC
通讯作者：
Bock,SC