MAP kinases in plant signal transduction: how many, and what for?
MAP kinases in plant signal transduction: how many, and what for?
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植物信号转导中的 MAP 激酶：有多少，有何用途？
DOI：
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发表时间：
2000
影响因子：
--
通讯作者：
W. Ligterink
中科院分区：
文献类型：
--
作者：
W. Ligterink
丝裂原活化蛋白激酶（MAPK）通路是一种蛋白激酶级联反应，在所有真核生物中具有将细胞外信号转导至细胞内靶点的功能。不同的MAPK通路由不同的信号调节，并在各种各样的生理过程中发挥作用。在植物中，有证据表明MAPKs在病原体、非生物胁迫、植物激素和细胞周期信号传导中发挥作用。在植物中已经鉴定出大量不同的MAPK，它们都与动物ERK MAPK最相似。通过序列比对，所有可用的全长植物MAPKs可分为五个亚家族。存在四个亚家族成员的功能数据，并显示不同的亚家族编码特定功能的MAPK。从全长，截短的cDNA和表达序列标签（EST）的部分MAPK序列的分析显示，在植物MAPK超家族中存在两个新的亚家族。签名序列有效的植物MAPKs的超家族和每个亚家族的推导和新的MAPKs的分类，应有助于未来。未来的挑战是明确分配每个MAPK的功能，并破译其信号通路的其他伙伴。
Mitogen-activated protein kinase (MAPK) pathways are protein kinase cascades that have a function in the transduction of extracellular signals to intracellular targets in all eukaryotes. Distinct MAPK pathways are regulated by different signals and have a role in a wide variety of physiological processes. In plants there is evidence for a role of MAPKs in the signaling of pathogens, abiotic stresses, plant hormones, and cell cycle cues. A large number of distinct MAPKs in plants have been identified that are all most similar to the animal ERK MAPKs. By sequence alignment all available full length plant MAPKs can be grouped into five subfamilies. Functional data exist for members of four subfamilies and show that different subfamilies encode MAPKs for specific functions. Analysis of partial MAPK sequences from full length, truncated cDNAs and expressed sequence tags (ESTs) revealed the presence of two new subfamilies in the plant MAPK superfamily. Signature sequences valid for the superfamily of plant MAPKs and each subfamily were derived and should help in future classification of novel MAPKs. The future challenge is to unambiguously assign functions to each MAPK and decipher the other partners of their signaling pathways.
DOI：
10.1073/pnas.94.6.2327
发表时间：
1997-03-18
影响因子：
11.1
作者：
Wang, ZL;Harkins, PC;Goldsmith, EJ
通讯作者：
Goldsmith, EJ