Dissociation of BDNF Val66Met polymorphism on neurocognitive functioning in military veterans with and without a history of remote mild traumatic brain injury.
Dissociation of BDNF Val66Met polymorphism on neurocognitive functioning in military veterans with and without a history of remote mild traumatic brain injury.
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BDNF Val66Met 多态性的分离对有或没有远程轻度创伤性脑损伤史的退伍军人神经认知功能的影响。
DOI：
10.1080/13854046.2020.1740324
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发表时间：
2020
期刊：
影响因子：
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通讯作者：
Delano-Wood,Lisa
中科院分区：
文献类型：
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作者：
Merritt,VictoriaC;Clark,AlexandraL;Evangelista,NicoleD;Sorg,ScottF;Schiehser,DawnM;Delano-Wood,Lisa
由于轻度创伤性脑损伤（mTBI）后的神经认知功能可能受到介导突触存活和修复的遗传因素的影响，我们研究了一种常见的脑源性神经营养因子（BDNF）多态性的影响。（Val 66 Met）对认知的影响，使用了一个明确定义的有和没有mTBI病史的退伍军人样本。（mTBI = 75;军事对照组[MC] = 63），他们接受了神经心理学测试，包括完成评估精神痛苦的自我报告措施和BDNF基因分型。mTBI组在最近一次mTBI后大约66.7个月进行了测试。退伍军人被分为两组-Met+（Met/Met和Met/瓦尔; n = 49）和Met-（瓦尔/瓦尔; n = 89），并在代表记忆、执行功能和视觉空间速度的特定领域认知综合评分上进行比较。Met−）相互作用的记忆（p= 0.024; ηp2= 0.039）和执行功能（p= 0.010; ηp2= 0.050）复合物，因此Met+ mTBI退伍军人在认知测量方面表现出比Met− mTBI退伍军人更好的表现，而Met+ MC在认知测量方面表现出相对于Met− MC更差的表现。没有观察到显著的相互作用的视觉空间速度复合（p= 0.938; ηp2<0.001）。结论这些发现提供了初步证据，表明Met等位基因可能是保护的背景下远程mTBI。研究结果需要使用更大的样本进行复制，未来的研究有必要阐明这种相互作用的精确机制和神经基础。
ObjectiveSince neurocognitive functioning following mild traumatic brain injury (mTBI) may be influenced by genetic factors that mediate synaptic survival and repair, we examined the influence of a common brain-derived neurotrophic factor (BDNF) polymorphism (Val66Met) on cognition using a well-defined sample of military Veterans with and without a history of mTBI.MethodParticipants included 138 Veterans (mTBI = 75; military controls [MCs] = 63) who underwent neuropsychological testing, including completion of self-report measures assessing psychiatric distress, and BDNF genotyping. The mTBI group was tested roughly 66.7 months following their most recent mTBI. Veterans were divided into two groups—Met+ (Met/Met and Met/Val; n = 49) and Met− (Val/Val; n = 89) and compared on domain-specific cognitive composite scores representing memory, executive functioning, and visuospatial speed.ResultsANCOVAs adjusting for psychiatric distress, sex, years of education, and ethnicity/race revealed a significant group (mTBI vs. MC) by BDNF genotype (Met + vs. Met−) interaction for the memory (p= .024; ηp2= .039) and executive functioning (p= .010; ηp2= .050) composites, such that Met+ mTBI Veterans demonstrated better performance than Met− mTBI Veterans on the cognitive measures, whereas Met+ MCs demonstrated worse performance relative to Met− MCs on the cognitive measures. No significant interaction was observed for the visuospatial speed composite (p= .938; ηp2< .001).ConclusionsThese findings offer preliminary evidence to suggest that the Met allele may be protective in the context of remote mTBI. Findings need to be replicated using larger samples, and future studies are necessary to elucidate the precise mechanisms and neural underpinnings of this interaction.