Rebaudioside A: Two-generation reproductive toxicity study in rats
Rebaudioside A: Two-generation reproductive toxicity study in rats
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DOI：
10.1016/j.fct.2008.05.005
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发表时间：
2008-07-01
影响因子：
4.3
通讯作者：
Brown, Nigel
中科院分区：
文献类型：
--
作者：
Curry, Leslie L.;Roberts, Ashley;Brown, Nigel
通过饮食给予雄性和雌性Han Wistar大鼠0、7500、12，500和25，000 ppm的莱鲍迪苷A，持续两代。莱鲍迪苷A治疗与任何临床毒性体征或对体重、体重增加或食物消耗的不良影响无关。在F-0或F-1代中均未观察到莱鲍迪苷A对生殖性能参数（包括交配性能、生育力、妊娠期长度、发情周期或精子活力、浓度或形态）的处理相关影响。F-1和F-2后代的存活率和一般状况、它们的断奶前反射发育、总体体重增加和性成熟的时间没有受到莱鲍迪苷A处理的不利影响。生殖影响的NOAEL为25，000 ppm，后代存活、发育和一般状况的NOAEL也被认为是25，000 ppm或2048-2273 mg/kg体重/天。(c)2008爱思唯尔有限公司保留所有权利。
Rebaudioside A was administered via the diet to male and female Han Wistar rats at 0, 7500, 12,500, and 25,000 ppm for two generations. Rebaudioside A treatment was not associated with any signs of clinical toxicity or adverse effects on body weight, body weight gain, or food consumption. No treatment-related effects of rebaudioside A were observed in either the F-0 or F-1 generations on reproductive performance parameters including mating performance, fertility, gestation lengths, oestrous cycles, or sperm motility, concentration, or morphology. The survival and general condition of the F-1 and F-2 offspring, their pre-weaning reflex development, overall body weight gains, and the timing of sexual maturation, were not adversely affected by rebaudioside A treatment. The NOAEL for reproductive effects was 25,000 ppm and the NOAEL for the survival, development, and general condition of the offspring also was considered to be 25,000 ppm or 2048-2273 mg/kg body weight/day. (c) 2008 Elsevier Ltd. All rights reserved.