Experimentally induced enlargement of the uncrossed retinotectal pathway in rats.
Experimentally induced enlargement of the uncrossed retinotectal pathway in rats.
复制标题
实验诱导大鼠非交叉视网膜顶盖通路扩大。
DOI：
10.1016/0006-8993(81)90065-2
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发表时间：
1981
期刊：
影响因子：
2.9
通讯作者：
Lund,RD
中科院分区：
文献类型：
--
作者：
Jen,LS;Lund,RD
本实验研究新生儿病变对白化病大鼠非交叉视网膜顶盖通路投射模式的影响。结果表明，扩大终端领域从一只眼睛可以引起对侧视束病变或删除对出生时的眼睛。在后一种情况下，扩大的程度更为突出。如果视束病变伴有视束病变同侧眼球摘除术，则其余眼球未交叉的视网膜顶盖投影将进一步增大。然而，光纤计数表明，这种扩大的终端领域是不是由于一个显着增加的数量未交叉的视神经轴突，这有助于扩大的投影，而是增加终端轴的个别轴突（如所示的结果从纤维计数）。虽然在对侧的视网膜中观察到严重的神经节细胞损失，但大量的细胞群体持续存在于神经节细胞层中，并且细胞的数量似乎远高于来自同一只眼睛的未交叉的视神经轴突的数量。这些研究结果的影响进行了讨论，在以前的研究报告的结果。
The present experiments investigate the effects of neonatal lesions upon projection patterns of the uncrossed retinotectal pathway in albino rats. The results indicate that enlargement of the terminal field from one eye can be induced either by a contralateral optic tract lesion or by removal of the opposite eye at birth. The extent of the enlargement is more prominent in the latter case. If an optic tract lesion is accompanied by eye enucleation on the side ipsilateral to the tract lesion, the uncrossed retinotectal projection from the remaining eye will undergo further enlargement. However, optic fiber counts show that such an enlargement of the terminal field is not due to a significant increase in the number of uncrossed optic axons which contribute to the enlarged projection, but rather to an increased terminal arbor of individual axons (as shown by results from fiber counts). While a severe ganglion cell loss was observed in the retina contralateral to a tract lesion, a substantial population of cells persists in the ganglion cell layer and the number of cells appears much higher than the number of uncrossed optic axons arising from the same eye. The implications of these findings are discussed in relation to results reported in previous studies.