Body side-specific control of motor activity during turning in a walking animal
Body side-specific control of motor activity during turning in a walking animal
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DOI：
10.7554/elife.13799
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发表时间：
2016-04-27
期刊：
影响因子：
7.7
通讯作者：
Bueschges, Ansgar
中科院分区：
文献类型：
--
作者：
Gruhn, Matthias;Rosenbaum, Philipp;Bueschges, Ansgar
动物和人类需要灵活地移动，以适应环境的要求。尽管对无脊椎动物和脊椎动物行走的神经控制进行了大量的研究，但调节运动行为所需的运动灵活性的机制在很大程度上仍然未知。在这里，我们研究了视觉运动诱导的转向和神经元机制的差异之间的腿运动的身体两侧的棍子昆虫Carausius morosus。我们目前的数据表明，在昆虫的转动运动学的产生是下降的单边命令，改变腿部电机输出通过任务特定的修改在处理本地的感觉反馈，以及修改的活动，本地中央模式生成网络的身体侧特定的方式。据我们所知，这是第一个研究，以证明这种修改的特异性，在一个定义的运动任务。
Animals and humans need to move deftly and flexibly to adapt to environmental demands. Despite a large body of work on the neural control of walking in invertebrates and vertebrates alike, the mechanisms underlying the motor flexibility that is needed to adjust the motor behavior remain largely unknown. Here, we investigated optomotor-induced turning and the neuronal mechanisms underlying the differences between the leg movements of the two body sides in the stick insect Carausius morosus. We present data to show that the generation of turning kinematics in an insect are the combined result of descending unilateral commands that change the leg motor output via task-specific modifications in the processing of local sensory feedback as well as modification of the activity of local central pattern generating networks in a body-side-specific way. To our knowledge, this is the first study to demonstrate the specificity of such modifications in a defined motor task.