Effect of prenatal exposure to phencyclidine on the postnatal development of the cholinergic system in the rat.
Effect of prenatal exposure to phencyclidine on the postnatal development of the cholinergic system in the rat.
复制标题
产前接触苯环己哌啶对大鼠产后胆碱能系统发育的影响。
DOI：
10.1159/000111849
复制
发表时间：
1990
影响因子：
2.9
通讯作者：
Takeda,H
中科院分区：
文献类型：
--
作者：
Howard,SG;Takeda,H
本研究旨在探讨出生前苯环利定(PCP)暴露对新生纹状体和大脑皮层胆碱能系统发育的影响。妊娠母鼠每日注射五氯苯酚(0.5 mg/kg，S.C.)。从受孕到分娩。在出生后第21天或35天，给仔鼠注射激发剂量的五氯苯酚(0.5 mg/kg皮下注射)。测量额叶皮质和新纹状体中乙酰胆碱和胆碱的水平，以及将氚标记的胆碱掺入新合成的乙酰胆碱中的情况。数据表明，即使在21天时，子宫内暴露于五氯苯酚的大鼠幼鼠对挑战剂量的五氯苯酚比生理盐水对照组更敏感。因此，即使在产前长期接触五氯苯酚，也没有形成对五氯苯酚的耐受性。
The purpose of this study was to examine the effect of prenatal exposure to phencyclidine (PCP) on the postnatal development of the cholinergic system in the neostriatum and the neocortex. Pregnant females were injected daily with PCP (0.5 mg/kg s.c.) from conception to parturition. On postnatal day 21 or 35, pups were injected with a challenge dose of PCP (0.5 mg/kg s.c). The levels of acetylcholine and choline were measured, as well as the incorporation of deuterium-labelled choline into newly synthesized acetylcholine in the frontal cortex and neostriatum. The data demonstrate that even at 21 days, rat pups exposed to PCP in utero were more sensitive to a challenge dose of PCP than the saline controls. Thus, a tolerance to PCP, even after a prolonged prenatal exposure did not develop.