Energy restriction in childhood and adolescence and risk of prostate cancer: Results from the Netherlands Cohort Study
Energy restriction in childhood and adolescence and risk of prostate cancer: Results from the Netherlands Cohort Study
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DOI：
10.1093/aje/154.6.530
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发表时间：
2001-09-15
影响因子：
5
通讯作者：
Lumey, LH
中科院分区：
文献类型：
--
作者：
Dirx, MJM;van den Brandt, PA;Lumey, LH
这项研究调查了前列腺癌风险和儿童时期能量限制之间的关系。研究人员对58，279名年龄在55-69岁之间的男性进行了研究，他们参加了荷兰饮食和癌症队列研究。1986年通过问卷调查收集了有关饮食和危险因素的信息。在荷兰饥饿冬季（1944-1945年）和第二次世界大战期间（1940-4944年）和父亲的就业状况在1932-1940年的经济萧条期间，作为暴露的指标，收集了更多的信息。采用病例队列方法。经过7.3年的随访（至1993年12月），903例前列腺癌病例可供分析。对所有前列腺癌病例进行了分析。1944-1945年居住在荷兰西部城市的男性前列腺癌发病率为1.15（95%置信区间（CI）：0.80，1.31），1944-1945年居住在西部农村地区的男性前列腺癌发病率为1.30（95% CI：0.97，1.73）。战争年代（1940-1944年）的居住地和父亲在1932-1940年的就业与前列腺癌的风险无关。在对青少年生长突增期之前、期间和之后的暴露进行评价的亚组分析中，显示了与总体数据相同的模式。作者没有发现证据支持生命早期能量限制会降低生命后期前列腺癌风险的假设。
This study investigated the association between prostate cancer risk and energy restriction during childhood. The authors examined the hypothesis among 58,279 men aged 55-69 years enrolled in the Netherlands Cohort Study on Diet and Cancer. Information on diet and risk factors was collected by questionnaire in 1986. Additional information was collected on residence during the Dutch Hunger Winter (1944-1945) and the World War II years (1940-4944) and father's employment status during the economic depression of 1932-1940, used as indicators of exposure. A case-cohort approach was used. After 7.3 years of follow-up (through December 1993), 903 prostate cancer cases were available for analysis. Analyses were carried out for all prostate cancer cases. The prostate cancer rate ratio for men who had lived in a western Netherlands city in 1944-1945 was 1.15 (95% confidence interval (Cl): 0.80, 1.31), and the rate ratio for men who had lived in a western rural area in 1944-1945 was 1.30 (95% Cl: 0.97, 1.73). Residence during the war years (1940-1944) and father's employment in 1932-1940 showed no relation to prostate cancer risk. In subgroup analyses in which exposure before, during, and after the adolescent growth spurt was evaluated, the same pattern as that of the overall data was shown.. The authors found no evidence for the hypothesis that energy restriction early in life decreases prostate cancer risk later in life.