Recent development in additive modulated stereoselective glycosidation reactions
Recent development in additive modulated stereoselective glycosidation reactions
复制标题
DOI：
10.1080/07328303.2022.2027432
复制
发表时间：
2021-11
影响因子：
1
通讯作者：
Miaomiao Zhang;Tianlu Li;Peng Peng-Peng
中科院分区：
文献类型：
--
作者：
Miaomiao Zhang;Tianlu Li;Peng Peng-Peng
立体选择性糖苷键的形成（称为“糖苷化”）仍然是碳水化合物化学中的一个挑战。尽管存在这些困难，但仍制定了各种创新战略。特别是，添加剂调节的立体选择性的糖苷键的建设已成为一个新兴的趋势。本文从硫代糖苷类、糖基亚氨酸类、糖基乙酸类、糖基半缩醛类、糖基磷酸酯类和糖基邻炔基苯甲酸酯类等糖基供体出发，综述了近年来糖基供体的研究进展。连同它们的优点/局限性，这些成就揭示了碳水化合物化学，并使复杂的寡糖和糖缀合物的有效制备成为可能。图形摘要
Abstract Stereoselective glycosidic bond formation (termed “glycosidation”) remains a challenge in carbohydrate chemistry. Despite such difficulty, a variety of innovative strategies have been developed. In particular, additive-modulated stereoselective construction of glycosidic linkages has become an emerging trend. In this review, we summarized the recent progress in this area with respect to common glycosyl donors, including thioglycosides, glycosyl imidates, glycosyl acetates, glycosyl hemiacetals, glycosyl phosphates and glycosyl ortho-alkynylbenzoates. Together with their merits/limitations, these achievements shed light on carbohydrate chemistry and enabled the efficient preparation of complex oligosaccharides and glycoconjugates. Graphical Abstract