Mechanisms of endothelial senescence
Mechanisms of endothelial senescence
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DOI：
10.1113/expphysiol.2008.043133
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发表时间：
2009-03-01
影响因子：
2.7
通讯作者：
Skene, Chris
中科院分区：
文献类型：
--
作者：
Erusalimsky, Jorge D.;Skene, Chris
当来自不同血管床的内皮细胞在培养物中生长时，它们显示出有限的分裂能力，最终进入称为“复制性衰老”的永久和表型独特的非分裂状态。复制性衰老被认为是端粒DNA进行性缩短和随之而来的端粒功能障碍的结果。最近，人们已经认识到，衰老也可以由各种损伤诱导，包括那些引起细胞内氧化应激。在这份报告中，我们审查的证据发生内皮细胞衰老在体内。我们还将研究这一过程的原因，机制和调控，因为它们出现在我们的研究在细胞培养中，特别关注氧化应激，端粒酶，生长因子和一氧化氮的作用。
When endothelial cells from different vascular beds are grown in culture they show a limited capacity to divide, eventually entering into a permanent and phenotypically distinctive non-dividing state referred to as 'replicative senescence'. Replicative senescence is thought to result from progressive shortening of telomeric DNA and consequent telomere dysfunction. More recently, it has been realised that senescence can also be induced by a variety of insults, including those causing intracellular oxidative stress. In this report, we review evidence for the occurrence of endothelial cell senescence in vivo. We will also examine the causes, mechanisms and regulation of this process as they emerge from our studies in cell culture, focusing in particular on the roles of oxidative stress, telomerase, growth factors and nitric oxide.