Osteogenic capacities of tibial and cranial periosteum: A biochemical and histologic study
Osteogenic capacities of tibial and cranial periosteum: A biochemical and histologic study
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DOI：
10.1097/scs.0b013e318052fe3d
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发表时间：
2008-03-01
影响因子：
0.9
通讯作者：
Songur, Ecmel
中科院分区：
文献类型：
--
作者：
Bilkay, Ufuk;Tokat, Cenk;Songur, Ecmel
骨膜在骨再生中具有重要作用。本研究的目的是评价和比较胫骨和颅骨骨膜的成骨能力。为了实现这一点，将44只新西兰雄性家兔分为两组，每组22只家兔。第1组，在每侧小腿后侧胫骨上制备骨膜瓣。第2组在颅骨区制备双侧骨膜瓣。通过测量碱性磷酸酶和骨钙素水平定量估计新骨形成，因为它们是成骨细胞活性的指标。在第1、2、4和8周，从每组的5只动物中采集活检组织用于生化分析，在第2和8周，采集活检组织用于组织学评价。在第1组中评估了较高的碱性磷酸酶和骨钙素水平，并且在第1组中观察到更多的骨形成。结果表明，胫骨骨膜的成骨能力高于颅骨骨膜。
The periosteum has an important role in bone regeneration. The purpose of this study was to evaluate and compare the osteogenic capacities of tibial and cranial periosteum. To achieve this, 44 New Zealand male rabbits were divided into two groups, each consisting of 22 rabbits. In group 1, periosteal flaps were prepared on the tibia of the posterior cruris of each side. In group 2, bilateral periosteal flaps were prepared on the cranial region. New bone formation was estimated quantitatively by measuring the alkaline phosphatase and osteocalcin levels, because they are the indicators of osteoblastic activity. At weeks 1, 2, 4, and 8, biopsies were taken from five animals of each group for biochemical analyses, and at weeks 2 and 8, biopsies were taken for histologic evaluation. Higher alkaline phosphatase and osteocalcin levels were evaluated in group 1, and more bone formation was observed in group 1. The results showed that osteogenic capacity is higher in tibial periosteum than cranial periosteum.