Corticolimbic Function in Impulsive Aggressive Behavior
Corticolimbic Function in Impulsive Aggressive Behavior
复制标题
DOI：
10.1016/j.biopsych.2011.02.032
复制
发表时间：
2011-06-15
影响因子：
10.6
通讯作者：
Phan, K. Luan
中科院分区：
文献类型：
--
作者：
Coccaro, Emil F.;Sripada, Chandra Sekhar;Phan, K. Luan
基于动物和人类损伤的证据，神经影像学研究越来越多地发现皮质边缘回路介导攻击行为的异常。这篇综述集中在三个神经系统参与冲动/反应性攻击：1）皮层下神经系统，支持生产的攻击性冲动; 2）决策电路和社会情绪信息处理电路，评估的后果，攻击或不攻击;和3）额顶叶区域，参与调节情绪和冲动的动机冲动。我们回顾精神疾病，包括边缘型人格障碍和反社会型人格障碍，其特点是反应性攻击升高，重点是这三个神经系统的异常。
Building on animal and human lesion evidence, neuroimaging studies are increasingly identifying abnormalities in corticolimbic circuits mediating aggressive behavior. This review focuses on three neural systems involved in impulsive/reactive aggression: 1) subcortical neural systems that support the production of aggressive impulses; 2) decision-making circuits and social-emotional information processing circuits that evaluate the consequences of aggressing or not aggressing; and 3) frontoparietal regions that are involved in regulating emotions and impulsive motivational urges. We review psychiatric disorders, including borderline personality disorder and antisocial personality disorder, characterized by elevated reactive aggression, focusing on abnormalities in these three neural systems.