Injectable and biodegradable temperature-responsive mixed polymer systems providing variable gel-forming pH regions
Injectable and biodegradable temperature-responsive mixed polymer systems providing variable gel-forming pH regions
复制标题
DOI：
10.1080/09205063.2017.1304170
复制
发表时间：
2017-03
期刊：
影响因子：
--
通讯作者：
Y. Yoshida;Keisuke Kawahara;Shintaro Mitsumune;A. Kuzuya;Y. Ohya
中科院分区：
文献类型：
--
作者：
Y. Yoshida;Keisuke Kawahara;Shintaro Mitsumune;A. Kuzuya;Y. Ohya
摘要 可生物降解聚合物的水溶液在温度和 pH 值等外部刺激下表现出溶胶到凝胶的转变，有望用作生物医学应用的可注射聚合物 (IP)。在这项研究中，我们制备了新型可生物降解的温度响应型 IP 系统，提供可变的凝胶形成 pH 区域。我们合成了PCGA-b-PEG-b-PCGA (tri-PCG)，并在两个末端连接了羧酸或伯胺基团，tri-PCG-COOH和tri-PCG-NH2，并研究了这两种共聚物的混合物在不同pH值下的温度响应性溶胶到凝胶转变行为。我们发现，通过简单地改变这些聚合物的混合比例，可以轻松控制混合系统的凝胶形成 pH 范围。
Abstract Aqueous solutions of biodegradable polymers exhibiting sol-to-gel transitions in response to external stimuli such as temperature and pH are expected to be used as injectable polymers (IPs) for biomedical applications. In this study, we prepared novel biodegradable temperature-responsive IP systems providing variable gel-forming pH regions. We synthesized PCGA-b-PEG-b-PCGA (tri-PCG) and attached carboxylic acid or primary amine groups on both termini, tri-PCG-COOH and tri-PCG-NH2, and investigated the temperature-responsive sol-to-gel transition behavior of the mixtures of these two copolymers at various pHs. We found that the gel-forming pH region of the mixed system could be easily controlled by simply changing the mixing ratios of these polymers.