Botryotins A-H, Tetracyclic Diterpenoids Representing Three Carbon Skeletons from a Deep-Sea-Derived Botryotinia fuckeliana
Botryotins A-H, Tetracyclic Diterpenoids Representing Three Carbon Skeletons from a Deep-Sea-Derived Botryotinia fuckeliana
复制标题
Botryotins A–H，四环二萜类化合物，代表来自深海的 Botryotinia foleliana 的三个碳骨架
DOI：
10.1021/acs.orglett.9b04332
复制
发表时间：
2020-01-17
期刊：
影响因子：
5.2
通讯作者：
Yang, Xian-Wen
中科院分区：
文献类型：
--
作者：
Niu, Siwen;Xie, Chun-Lan;Yang, Xian-Wen
从灰霉病菌中分离得到8个未见文献报道的二萜类化合物，分别为葡萄糖苷A-H(1-8)。它们代表了三个新的碳骨架，分别是6/6/5/5(1)，6/6/5/6(2-6)和6/6/6/5(7和8)四环骨架。通过详细的光谱分析和化学衍生化以及ECD和OR数据的量子化学计算确定了它们的结构。葡萄糖苷A(1)具有中等的抗过敏作用(IC50=0.2 mM)。提出了1-8的生物合成途径。
Eight unprecedent diterpenoids, botryotins A-H (1-8), were obtained from Botryotinia fuckeliana. They represent three novel carbon skeletons with 6/6/5/5 (1), 6/6/5/6 (2-6), and 6/6/6/5 (7 and 8) tetracyclic scaffolds. Their structures were determined by detailed spectroscopic analysis and chemical derivatization as well as quantum chemical calculation of the ECD and OR data. Botryotin A (1) exhibited a moderate antiallergic effect (IC50 = 0.2 mM). A plausible biosynthetic pathway for 1-8 was proposed.