Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water
Associations between perfluoroalkyl substances and serum lipids in a Swedish adult population with contaminated drinking water
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DOI：
10.1186/s12940-020-00588-9
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发表时间：
2020-03-14
影响因子：
6
通讯作者：
Fletcher, Tony
中科院分区：
文献类型：
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作者：
Li, Ying;Barregard, Lars;Fletcher, Tony
背景在以前的研究中，暴露于全氟烷基物质（PFAS）与血脂呈正相关。虽然许多关于脂质的研究调查了与全氟辛烷磺酸（PFOS）和全氟辛酸（PFOA）的关系，但只有少数研究涉及其他全氟辛烷磺酸，如全氟己烷磺酸（PFHxS）。本研究的目的是调查是否存在与血脂的关联，不仅是血清中的全氟辛烷磺酸和全氟辛酸，而且还与PFHxS，以及是否与全氟辛烷磺酸的关联也保持在仅基于居住在全氟辛烷磺酸暴露对比地区的比较中。方法1945名年龄在20-60岁的成年人，包括从龙内比，瑞典，一个自治市，其中两个自来水厂之一已被严重污染的水性消防泡沫，并从附近的控制区。根据居住在PFAS暴露对比区域或根据实际血清PFAS测量值对暴露进行分类。血脂的回归分析与血清PFAS水平、百分位数组、光滑样条曲线以及暴露区和参考区之间进行拟合，并对年龄、性别和BMI进行调整。结果饮用水污染导致血清中PFOS（中位数157 ng/ml）、PFHxS（中位数136 ng/ml）和PFOA（中位数8.6 ng/ml）水平升高。暴露组的这些血清PFAS水平比对照组高5至100倍。在混合PFAS暴露人群中，主要是PFOS和PFHxS，PFAS暴露与血脂呈正相关。在定量暴露（作为暴露与对照之间的对比）和血清PFAS时均观察到这一点。由于每个PFAS之间的高度相关性，我们无法将它们分开。结论本研究进一步证实了PFAS与血脂，尤其是PFHxS之间的因果关系。
Background Exposures to perfluoroalkyl substances (PFAS) have shown positive associations with serum lipids in previous studies. While many studies on lipids investigated associations with perfluorooctane sulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), there are only a few studies regarding other PFAS, such as perfluorohexane sulfonic acid (PFHxS). The purpose of the current study is to investigate if associations with serum lipids were present, not only for serum PFOS and PFOA, but also for PFHxS, and if the associations with PFAS remained also in a comparison based only on residency in areas with contrasting exposure to PFAS. Methods 1945 adults aged 20-60 were included from Ronneby, Sweden, a municipality where one out of two waterworks had been heavily contaminated from aqueous fire-fighting foams, and from a nearby control area. The exposure was categorized based on either been living in areas with contrasting PFAS exposure or based on the actual serum PFAS measurements. Regression analyses of serum lipids were fitted against serum PFAS levels, percentile groups, smooth splines and between exposed and reference areas, adjusting for age, sex and BMI. Results Drinking water contamination caused high serum levels of PFOS (median 157 ng/ml) and PFHxS (median 136 ng/ml) and PFOA (median 8.6 ng/ml). These serum PFAS levels in the exposed groups were 5 to 100-fold higher than in the controls. In this population with mixed PFAS exposure, predominantly PFOS and PFHxS, PFAS exposure were positively associated with serum lipids. This was observed both when quantifying exposure as contrast between exposed and controls, and in terms of serum PFAS. Due to high correlations between each PFAS, we cannot separate them. Conclusions In conclusion, the present study provides further evidence of a causal association between PFAS and serum lipids, especially for PFHxS.