Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension
Independent association between inflammatory markers (C-reactive protein, interleukin-6, and TNF-α) and essential hypertension
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DOI：
10.1038/sj.jhh.1001785
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发表时间：
2005-02-01
影响因子：
2.7
通讯作者：
Gamarra, G
中科院分区：
文献类型：
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作者：
Bautista, LE;Vera, LM;Gamarra, G
高血压（HBP）与c反应蛋白（CRP）升高有关，c反应蛋白是慢性轻度炎症的标志。然而，HBP与其他炎症标志物，特别是白细胞介素6 （IL-6）和肿瘤坏死α (tnf - α)之间的关系尚未在对照良好的研究中得到评估。我们在196名健康受试者的随机样本中检测了IL-6、tnf - α、CRP和HBP之间的横断面关系。所有标记物均采用高灵敏度ELISA试验重复检测。在分析中取三个血压（BP）测量值的平均值，收缩压大于或等于140和/或舒张压大于或等于90 mmHg的受试者被认为是高血压。采用对数二项回归估计HBP的多变量校正患病率（PR）。在受试者中，40%（79）患有高血压（平均年龄44岁，范围30 - 64岁）。在调整年龄、性别、体重指数、HBP家族史和其他炎症标志物水平后，IL-6第二（PR: 3.10, P = 0.003）、第三（PR: 2.32, P = 0.031）和第四四分位数（PR: 2.30, P = 0.036）受试者发生高血压的可能性是第一四分位数受试者的两倍多。相应的tnf - α水平的PR估计为1.41 (P = 0.014)；第三组为1.59 (P = 0.001)；第四个四分位数为1.61 （P = 0.025）。CRP与HBP的相关性无统计学意义。我们的结果表明，tnf - α和IL-6可能是表面健康受试者的HBP的独立危险因素。然而，炎症标志物升高和HBP之间的时间关系应该在前瞻性队列研究中确定。
High blood pressure (HBP) has been associated with elevated C-reactive protein (CRP), a marker of chronic mild inflammation. However, the association between HBP and other inflammatory markers, particularly interleukin 6 ( IL-6) and tumour necrosis alpha (TNF-alpha), has not been evaluated in well-controlled studies. We examined the cross-sectional relationship between IL-6, TNF-alpha, and CRP and HBP in a random sample of 196 healthy subjects. All markers were measured in duplicate with high-sensitivity ELISA tests. Three blood pressure ( BP) measurments were averaged for the analysis, and subjects with systolic BP greater than or equal to140 and/or diastolic BP greater than or equal to90 mmHg were considered hypertensive. Log binomial regression was used to estimate multivariate-adjusted prevalence ratios ( PR) of HBP. Of the subjects, 40% (79) were hypertensive ( mean age: 44 years; range 30 - 64). After adjustment for age, sex, body mass index, family history of HBP, and the level of the other inflammatory markers, subjects in the second ( PR: 3.10, P = 0.003), third ( PR: 2.32; P = 0.031), and fourth quartiles ( PR: 2.30; P = 0.036) of IL-6 were more than twice as likely to be hypertensive than those in the first quartile. Corresponding PR estimates for TNF-alpha levels were 1.41 ( P = 0.014) for the second; 1.59 ( P = 0.001) for the third; and 1.61 ( P = 0.025) for the fourth quartile. The CRP - HBP association was not statistically significant. Our results suggest that TNF-alpha and IL-6 could be independent risk factors for HBP in apparently healthy subjects. Nevertheless, the temporal relationship between elevated inflammation markers and HBP should be ascertained in prospective cohort studies.