Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis
Potent antitumor efficacy of interleukin-18 delivered by conditionally replicative adenovirus vector in renal cell carcinoma-bearing nude mice via inhibition of angiogenesis
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条件复制腺病毒载体传递白细胞介素18通过抑制血管生成对荷肾细胞癌裸鼠具有有效的抗肿瘤功效
DOI：
10.4161/cbt.8.7.7914
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发表时间：
2009-04
影响因子：
3.6
通讯作者：
Zheng JN, Pei DS, Sun FH, Liu XY, Mao LJ, Zhang BF
中科院分区：
文献类型：
--
作者：
Zheng JN, Pei DS, Sun FH, Liu XY, Mao LJ, Zhang BF
白细胞介素18（IL-18）具有抗肿瘤活性。在这项研究中，我们研究了溶瘤腺病毒介导的IL-18基因转移是否可以诱导强的抗肿瘤活性。通过将IL-18表达盒插入到基于腺病毒E1 B 55-kDa基因缺失的ZD 55载体中，构建了表达IL-18的肿瘤选择性复制型腺病毒（ZD 55-IL-18）。ZD 55-IL-18表达IL-18的能力明显高于Ad-IL-18。研究表明，ZD 55-IL-18对肾癌细胞有较强的致细胞病变作用和明显的凋亡作用。ZD 55-IL-18显著降低肿瘤细胞中VEGF和CD 34的表达。用ZD 55-IL-18处理已建立的肿瘤显示出比由ZD 55-EGFP或Ad-IL-18诱导的抗肿瘤活性更强的抗肿瘤活性。这些数据表明，表达IL-18的溶瘤腺病毒可以通过抑制血管生成发挥潜在的抗肿瘤活性，为癌症治疗提供了一种新的方法。
It has been demonstrated that interleukin 18 (IL-18) exerts antitumor activity. In this study, we investigated whether oncolytic adenovirus-mediated gene transfer of IL-18 could induce strong antitumor activity. A tumor-selective replicating adenovirus expressing IL-18 (ZD55-IL-18) was constructed by insertion of an IL-18 expression cassette into the ZD55 vector, which is based on deletion of the adenoviral E1B 55-kDa gene. ZD55-IL-18 could express substantially more IL-18 than Ad-IL-18 because of replication of the vector. It has been shown that ZD55-IL-18 exerted a strong cytopathic effect and significant apoptosis in renal cell carcinoma. ZD55-IL-18 significantly decreased VEGF and CD34 expression in the tumor cells. Treatment of established tumors with ZD55-IL-18 showed much stronger antitumor activity than that induced by ZD55-EGFP or Ad-IL-18. These data indicated that oncolytic adenovirus expressing IL-18 could exert potential antitumor activity via inhibition of angiogenesis and offer a novel approach to cancer therapy.
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影响因子：
3.8
作者：
Chang CY;Lee J;Kim EY;Park HJ;Kwon CH;Joh JW;Kim SJ
通讯作者：
Kim SJ
影响因子：
11.2
作者：
Carla Heise;Angelica Williams;Shirley Xue;Meisa Propst;D. Kirn
通讯作者：
Carla Heise;Angelica Williams;Shirley Xue;Meisa Propst;D. Kirn
DOI：
10.1136/bmj.g4797
发表时间：
2014-11-10
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Jonasch E;Gao J;Rathmell WK
通讯作者：
Rathmell WK
影响因子：
2
作者：
F. Okano;K. Yamada
通讯作者：
F. Okano;K. Yamada
影响因子：
5.4
作者：
Rothmann, T;Hengstermann, A;zur Hausen, H
通讯作者：
zur Hausen, H