Effect and Placental Transfer of Dexmedetomidine During Caesarean SectionUnder General Anaesthesia
Effect and Placental Transfer of Dexmedetomidine During Caesarean SectionUnder General Anaesthesia
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DOI：
10.1111/bcpt.12389
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发表时间：
2015-09-01
影响因子：
3.1
通讯作者：
Ding, Zhengnian
中科院分区：
文献类型：
--
作者：
Yu, Min;Han, Chuanbao;Ding, Zhengnian
许多药物可以通过胎盘并对胎儿造成不良影响。因此，在对有椎管内麻醉禁忌症的产妇进行剖腹产时，使用对产妇有镇静、镇痛作用而对胎儿无不良影响的适当药物是很重要的。在这项研究中，我们研究了右美托咪定在全身麻醉下剖宫产术中的作用和胎盘转移。将38名产妇随机分为麻醉诱导前和手术期间接受右美托咪定或生理盐水。右美托咪定治疗的产妇在分娩时和手术结束时的平均动脉压和心率较低。右美托咪啶治疗的产妇也需要比盐水治疗的产妇少5.5%的丙泊酚和8.4%的芬太尼。右美托咪定组产妇动脉、脐静脉、脐动脉血气分析结果及新生儿Apgar评分与生理盐水组比较，差异无统计学意义（P > 0. 05）。分娩后。右美托咪定的胎盘转移率为0.76。我们得出结论，右美托咪定可有效维持全身麻醉下剖宫产术期间产妇的血流动力学稳定，且不会对新生儿产生不良影响。右美托咪定可通过胎盘，胎盘转移率为0.76。
Many drugs can pass through the placenta and cause adverse effects on the foetus. Thus, during Caesarean section for puerperas who have contraindications for intravertebral anaesthesia, the use of proper drugs that have sedative, analgesic effects on the puerperas without adverse effects on the foetus is important. In this study, we investigated the effect and placental transfer of dexmedetomidine during Caesarean section under general anaesthesia. Thirty-eight puerperas were randomly divided to receive dexmedetomidine or saline before anaesthesia induction and during the operation. The dexmedetomidine-treated parturients had lower mean arterial pressure and heart rate at the delivery and at the end of the operation. The dexmedetomidine-treated parturients also needed 5.5% less propofol and 8.4% less fentanyl than the saline-treated ones. Between the dexmedetomidine-treated and saline-treated parturients, there was no difference in the maternal artery, umbilical vein, umbilical artery blood gas analysis results and the Apgar scores at 1 and 5min. after delivery. The placental transfer rate of dexmedetomidine was 0.76. We concluded that dexmedetomidine was effective in maintaining the haemodynamic stability in the parturients during Caesarean section under general anaesthesia without adverse neonatal effects. Dexmedetomidine can pass through the placenta with a placental transfer rate of 0.76.