Gene expression profiles in normal and cancer cells
Gene expression profiles in normal and cancer cells
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DOI：
10.1126/science.276.5316.1268
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发表时间：
1997-05-23
期刊：
影响因子：
56.9
通讯作者：
Kinzler, KW
中科院分区：
文献类型：
--
作者：
Zhang, L;Zhou, W;Kinzler, KW
作为了解人类正常细胞和癌细胞之间复杂差异的一步，研究了胃肠道肿瘤的基因表达模式。分析了来自至少45，000个不同基因的300，000多个转录本。虽然广泛的相似性，注意到之间的表达谱，超过500个转录本，在正常和肿瘤细胞中表达的显着不同的水平进行了鉴定。这些数据提供了深入了解表达差异的程度，潜在的恶性肿瘤和揭示基因，可能被证明是有用的诊断或预后标志物。
As a step toward understanding the complex differences between normal and cancer cells in humans, gene expression patterns were examined in gastrointestinal tumors. More than 300,000 transcripts derived from at least 45,000 different genes were analyzed. Although extensive similarity was noted between the expression profiles, more than 500 transcripts that were expressed at significantly different levels in normal and neoplastic cells were identified. These data provide insight into the extent of expression differences underlying malignancy and reveal genes that may prove useful as diagnostic or prognostic markers.