Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and α-linolenic acids on piglet brain monoaminergic neurotransmitters
Diverse, region-specific effects of addition of arachidonic and docosahexanoic acids to formula with low or adequate linoleic and α-linolenic acids on piglet brain monoaminergic neurotransmitters
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DOI：
10.1203/00006450-200007000-00022
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发表时间：
2000-07-01
影响因子：
3.6
通讯作者：
Innis, SM
中科院分区：
文献类型：
--
作者：
Owens, SD;Innis, SM
据报道，食用不同 omega-3 脂肪酸饮食的婴儿和动物在视觉、听觉和学习任务方面存在差异，但这些变化的神经生化基础尚不清楚。本研究调查了添加 0.8% 能量 C18:2 omega-6 + 0.05% C18:3 omega-3（低）或 8.3% C18:2 omega-6 + 0.8% C18:3 omega-3（充足）、添加或不添加 0.2% 能量花生四烯酸（C20:4 omega-6）和 0.16% 能量的配方奶的效果二十二碳六烯酸（C22:6 omega-3）对从出生到 18 天喂养配方奶的仔猪不同大脑区域的单胺能神经递质的影响。配方奶中C18:2 omega-6+C18:3 omega-3的添加量对额叶皮层多巴胺、3,4-二羟基苯乙酸、高香草酸、血清素和5-羟基吲哚乙酸有显着影响；纹状体血清素和下丘血清素，导致与充足的 C18:2 omega-6 + C18:3 omega-3 配方奶相比，饲喂低浓度仔猪的浓度较低。在较低但不充足的 C18:2 omega-6 + C18:3 omega-3 配方中加入花生四烯酸和二十二碳六烯酸，导致额叶皮质、纹状体和下丘血清素中所有单胺的浓度增加。在配方中添加花生四烯酸和二十二碳六烯酸可以增加上丘和下丘中与视觉和听觉信息处理和整合相关的区域的多巴胺和 5-羟基吲哚乙酸。即使在 C18:2 omega-6 + C18:3 omega-3 充足配方中添加花生四烯酸和二十二碳六烯酸，在这些区域中仍发现较高的多巴胺和 5-羟基吲哚乙酸。这项研究表明，食用不同 omega-6 和 omega-3 脂肪酸饮食的动物和婴儿的功能变化可能涉及神经递质代谢的改变。
Differences in visual, auditory, and learning tasks have been reported for infants and animals given diets varying in omega-3 fatty acids, but the neurobiochemical basis for these changes is unclear. This study investigated the effect of feeding formula with 0.8% energy C18:2 omega-6 + 0.05% C18:3 omega-3 (low), or 8.3% C18:2 omega-6 + 0.8% C18:3 omega-3 (adequate), with and without 0.2% energy arachidonic acid (C20:4 omega-6) and 0.16% docosahexanoic acid (C22:6 omega-3), on monoaminergic neurotransmitters in different brain regions of piglets fed formula from birth to 18 d. The amount of C18:2 omega-6 + C18:3 omega-3 fed in formula had a significant effect on frontal cortex dopamine, 3,4-dihydroxyphenylacetic acid, homovanillic acid, serotonin, and 5-hydroxyindolacetic acid; striatum serotonin and inferior colliculus serotonin, resulting in lower concentrations in piglets fed the low compared with adequate C18:2 omega-6 + C18:3 omega-3 formula. Inclusion of arachidonic acid and docosahexanoic acid in the low, but not in the adequate, C18:2 omega-6 + C18:3 omega-3 formula resulted in increased concentrations of all monoamines in the frontal cortex, and in striatum and inferior colliculus serotonin. Feeding arachidonic acid and docosahexanoic acid in the formulas increased dopamine and 5-hydroxyindolacetic acid in superior and inferior colliculus, areas related to processing and integration of visual and auditory information. Higher dopamine and 5-hydroxyindolacetic acid were found in these regions even when arachidonic acid and docosahexanoic acid were added to the C18:2 omega-6 + C18:3 omega-3 adequate formula. This study suggests that functional changes among animals and infants fed diets varying in omega-6 and omega-3 fatty acids may involve altered neurotransmitter metabolism.