Multiscale systems modeling of the tetralogy of Fallot
Multiscale systems modeling of the tetralogy of Fallot
复制标题
法洛四联症的多尺度系统建模
DOI：
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
J. Schleich
中科院分区：
文献类型：
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作者：
R. Summers;T. Abdulla;Ryan A. Imms;G. Carrault;Alfredo I. Hernández;L. Houyel;J. Schleich
本文提供了一个多尺度系统建模方法应用于先天性出生缺陷称为法洛四联症的第一个描述。所采用的多尺度方法在很大程度上归功于全球生理组联盟的努力和欧洲联盟内关于虚拟生理人的研究小组的工作。空间尺度和时间尺度被用来建立应用程序的系统边界。法洛四联症包括多达四个同时发生的解剖异常，支持缺陷。有限状态机和元胞自动机的使用为理解导致缺陷的时间和空间过程铺平了道路。
This paper provides a first description of a multiscale systems modeling approach applied to the congenital birth defect known as the tetralogy of Fallot. The multiscale approach adopted owes a lot to the effort of the world-wide physiome consortium and the work of research groups within the European Union on the Virtual Physiological Human. Both a spatial scale and time scale are used to establish the systems boundaries of the application. The tetralogy of Fallot includes up to four simultaneously occurring anatomic abnormalities that underpin the defect. The use of finite state machines and cellular automata pave the way to understand the processes in time and space that contribute to the defect.