Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT.
Overexpression of MICAL2, a novel tumor-promoting factor, accelerates tumor progression through regulating cell proliferation and EMT.
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MICAL2（一种新型肿瘤促进因子）的过表达通过调节细胞增殖和 EMT 加速肿瘤进展
DOI：
10.7150/jca.22355
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发表时间：
2018
影响因子：
3.9
通讯作者：
Tang F
中科院分区：
文献类型：
--
作者：
Cai Y;Lu J;Tang F
Molecule interacting with CasL 2 (MICAL2), a microtubule associated monooxygenase, is involved in cell growth, axon guidance, vesicle trafficking and apoptosis. Recent studies have demonstrated that MICAL2 is highly expressed in tumor and accelerates tumor progression and it is deemed to be a novel tumor-promoting factor. MICAL2 overexpression increases cell proliferation to accelerate tumor growth, and MICAL2 also promotes epithelial-mesenchymal transition (EMT)-related proteins to increase cancer cell metastasis. On mechanism, MICAL2 induces EMT by regulating SRF (serum response factor)/MRTF-A (myocardin related transcription factor A) signaling, Semaphorin/Plexin pathway and inducing ROS (Reactive oxygen species) production. In the present review, we introduced MICAL family, expatiated the structure and functions of MICALs, and summarized the mechanisms of MICAL2 involving tumor progression. The challenges and perspectives for MICAL2 in tumor are also discussed.
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影响因子：
--
作者：
Mariotti S;Barravecchia I;Vindigni C;Pucci A;Balsamo M;Libro R;Senchenko V;Dmitriev A;Jacchetti E;Cecchini M;Roviello F;Lai M;Broccoli V;Andreazzoli M;Mazzanti CM;Angeloni D
通讯作者：
Angeloni D
Mical Link将信号量与F-肌动蛋白拆卸。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
4
作者：
Leitner, Laura;Shaposhnikov, Dmitry;Posern, Guido
通讯作者：
Posern, Guido
影响因子：
4.6
作者：
Alqassim SS;Urquiza M;Borgnia E;Nagib M;Amzel LM;Bianchet MA
通讯作者：
Bianchet MA
影响因子：
--
作者：
Giridharan SS;Cai B;Naslavsky N;Caplan S
通讯作者：
Caplan S