Update on dopamine receptors.
Update on dopamine receptors.
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DOI：
10.3109/10401239409148986
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发表时间：
1994-06-01
期刊：
影响因子：
--
通讯作者：
Meador-Woodruff, J H
中科院分区：
文献类型：
--
作者：
Meador-Woodruff, J H
本文综述了多巴胺受体生物学的最新进展，重点介绍了我们最近对多巴胺受体各种基因表达的解剖位置的理解。至少已经发现了5种编码多巴胺受体的基因。这五种受体具有不同的药理学特征以及独特的神经解剖学分布。虽然D1和D2受体在许多神经系统中广泛表达，但新的D3和D4受体似乎集中在边缘系统的部分区域，而D5受体的分布有限且不寻常。每种多巴胺受体在大脑中的独特分布有助于对精神分裂症等精神疾病的潜在神经化学和神经解剖学基础的新认识，允许对精神药物的观察作用和副作用的理解，并为合理开发具有多巴胺能系统作用的新药提供线索。
This paper reviews recent developments in dopamine receptor biology, with an emphasis on our recent understanding of the anatomical locations of where various genes for the dopamine receptors are expressed. At least five genes encoding dopamine receptors have been discovered. These five receptors have distinct pharmacological profiles as well as unique neuroanatomical distributions. While D1 and D2 receptors are widely expressed in many neural systems, the novel D3 and D4 receptors appear to be concentrated within parts of the limbic system, and the D5 receptor has a limited and unusual distribution. The distinct distributions of each of the dopamine receptors in brain facilitates a new understanding of potential neurochemical and neuroanatomical substrates of psychiatric illnesses such as schizophrenia, permits an understanding of observed actions and side effects of psychotropic agents, and provides clues for the rational development of new drugs with effects in the dopaminergic system.