An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol
An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol
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DOI：
10.1016/j.tet.2007.06.071
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发表时间：
2007-09-10
期刊：
影响因子：
2.1
通讯作者：
Gill, Andrew A.
中科院分区：
文献类型：
--
作者：
Clarke, Paul A.;Rolla, Gabriele A.;Gill, Andrew A.
改进了（2 E，4 Z）-6-苄氧基-4-溴己-2，4-二烯-1-醇的合成方法。这种新的路线通过避免硼酸中间体的低产率制备以及消除使用多克量的高毒性铊盐的需要来增加二烯产物的生产量和产率。在开发该新路线的过程中，还实现了（E）-3-羟基丙-1-烯基硼酸的高产率制备。(c)2007爱思唯尔有限公司保留所有权利。
An improved synthesis of (2E,4Z)-6-(benzyloxy)-4-bromohexa-2,4-dien-1-ol has been devised. This new route increases the throughput and yield of the diene product by circumventing a low yielding preparation of boronic acid intermediate as well as removing the need to use multi-gram quantities of highly toxic thallium salts. In the process of developing this new route, a higher yielding preparation of ( E)-3-hydroxyprop-1-enylboronic acid was also achieved. (c) 2007 Elsevier Ltd. All rights reserved.