Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis
Synovial inflammation assessed by ultrasonography correlates with MRI-proven osteitis in patients with rheumatoid arthritis
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DOI：
10.1093/rheumatology/keu034
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发表时间：
2014-08-01
期刊：
影响因子：
5.5
通讯作者：
Kawakami, Atsushi
中科院分区：
文献类型：
--
作者：
Kawashiri, Shin-ya;Suzuki, Takahisa;Kawakami, Atsushi
客观的。本研究的目的是探讨超声检查评估滑膜炎症是否与 MRI 证实的 RA 患者骨炎相关。方法。连续纳入 30 名符合 2010 年 RA 分类标准且未接受过 DMARD（包括生物制剂和糖皮质激素）的 RA 患者。采用欧洲抗风湿病联盟提出的方法评估手腕和 MCP 关节滑膜炎和骨侵蚀的灰度 (GS) 和能量多普勒 (PD) 图像。还使用 RA MRI 评分系统 (RAMRIS) 在 3 天内对经 MRI 证实的相同部位的骨炎进行了评估。使用 Cochran-Armitage 检验和 Spearman 相关系数来研究每个超声检查结果与 MRI 证实的骨炎的相关性。结果。经 MRI 证实，8.3% 的 MCP 关节和 48.3% 的腕关节存在骨炎。其患病率在关节滑膜炎 GS 或 PD 等级为 2 或 3 级的关节中增加。此外，MRI 证实的骨炎优先发现于超声骨侵蚀呈阳性的关节中。 MCP 关节和腕关节的关节滑膜炎 GS 或 PD 等级或 US 骨侵蚀的存在与 RAMRIS 骨炎评分之间存在明显的相关性。结论。我们的数据表明，美国评估的关节损伤与 RA 患者经 MRI 证实的骨炎相关。
Objective. The aim of this study was to explore whether assessment of synovial inflammation by ultrasonography correlates with MRI-proven osteitis in patients with RA.Methods. Thirty RA patients who fulfilled 2010 RA classification criteria and were naive to DMARDs, including biologics and glucocorticoids, were consecutively enrolled in this study. Grey scale (GS) and power Doppler (PD) images of articular synovitis and bone erosion in both wrist and MCP joints were evaluated by the method proposed by the European League Against Rheumatism. MRI-proven osteitis of the identical sites was also evaluated within 3 days using the RA MRI scoring system (RAMRIS). The Cochran-Armitage test and Spearman's correlation coefficient were used to investigate the correlation of each US finding with MRI-proven osteitis.Results. MRI-proven osteitis was found in 8.3% of MCP joints and 48.3% of wrist joints. Its prevalence was increased in the joints where the GS or PD grade of articular synovitis was 2 or 3. In addition, MRI-proven osteitis was found preferentially in the joints positive for bone erosion on US. A clear correlation was demonstrated between the GS or PD grade of articular synovitis or the presence of US bone erosion and RAMRIS osteitis score in both MCP joints and wrist joints.Conclusion. Our data indicate that joint injury assessed by US correlates with MRI-proven osteitis in patients with RA.