Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements
Efficient Removal of Protecting Groups by a 'Push-Pull' Mechanism. II. Deprotection of O-Benzyltyrosine with a Thioanisole-Trifluoroacetic Acid System without O-to-C Rearrangements
复制标题
通过“推拉”机制有效去除保护基团。
DOI：
10.1248/cpb.28.673
复制
发表时间：
1980
影响因子：
1.7
通讯作者：
T. Akita
中科院分区：
文献类型：
--
作者：
Y. Kiso;K. Ukawa;Nakamura Shizuo;Kaoru Ito;T. Akita
A thioanisole-trifluoroacetic acid (TFA) system was found to deprotect Tyr (Bzl) quantitatively at 25°within 3 hr by a push-pull mechanism without O-to-C rearrangements. This new deblocking system did not completely deprotect Ser (Bzl) and Thr (Bzl), but deprotected Lys (Z) quantitatively.
