Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects
Increased density of microtubule associated protein 2-immunoreactive neurons in the prefrontal white matter of schizophrenic subjects
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DOI：
10.1016/0920-9964(96)88521-5
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发表时间：
1996-05-01
影响因子：
4.5
通讯作者：
Lewis, DA
中科院分区：
文献类型：
--
作者：
Anderson, SA;Volk, DW;Lewis, DA
最近的研究表明，精神分裂症可能与产前皮质亚板的紊乱有关，皮质亚板是形成大脑皮质回路的短暂但重要的结构。虽然大多数亚板神经元在发育后期死亡，但仍有一些作为成体白色物质的间质神经元保留下来。在这项研究中，我们使用了一种单克隆抗体对细胞骨架蛋白，微管相关蛋白-2（MAP 2），以量化的密度和分布标记的神经元在死后的大脑标本含有前额叶白色物质从5例精神分裂症和匹配的控制。在精神分裂症患者和对照组中，白色神经元的密度随着白色深度的增加而降低。然而，MAP 2-免疫反应神经元的平均密度更大的精神分裂症患者的表面白色问题相比，匹配的控制。相反，在较深的白色物质中，标记神经元的密度没有差异。这些发现与至少在某些精神分裂症病例中皮质基板发育异常一致。
Recent studies have suggested that schizophrenia may be related to prenatal disturbances in the cortical subplate, a transient but essential structure in the formation of cerebral cortical circuitry. Although most subplate neurons die during later development, some remain as the interstitial neurons of the adult white matter. In this study we used a monoclonal antibody against the cytoskeletal protein, microtubule associated protein-2 (MAP2), to quantify the density and distribution of labeled neurons in postmortem brain specimens containing the prefrontal white matter from five schizophrenic cases and matched controls. In both schizophrenics and matched controls, the density of white matter neurons decreased with increasing white matter depth. However, the mean density of MAP2-immunoreactive neurons was greater in the superficial white matter of the schizophrenic subjects compared to the matched controls. In contrast, no difference in the density of labeled neurons was seen in the deeper white matter. These findings are consistent with an abnormality in the development of the cortical subplate in at least some cases of schizophrenia.