"Dose-painting": Myth or reality?
"Dose-painting": Myth or reality?
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DOI：
10.1016/j.canrad.2010.06.005
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发表时间：
2010-10-01
影响因子：
1.3
通讯作者：
Fenoglietto, P.
中科院分区：
文献类型：
--
作者：
Supiot, S.;Lisbona, A.;Fenoglietto, P.
“剂量描绘”放射疗法允许通过靶向由功能成像限定的抗辐射区域在肿瘤体积内异质递送辐射。在总肿瘤体积内，可以基于生物学定义一个或多个靶体积（生物靶体积[BTV]），并应用将向这些区域递送更高剂量的调强放射治疗（IMRT）策略。在这篇文献综述中，我们将重点介绍导致辐射抗性的生物学元素，以及如何对它们进行成像，然后我们将详细介绍这种方法所需的放射治疗技术，然后介绍各种情况下的临床结果（头颈部肿瘤，前列腺，脑肿瘤等）。尽管目前常规IMRT的剂量绘制存在许多困难，但生物学引导的放射治疗是未来几年放射治疗发展的主要途径之一。(C)2010法国放射治疗肿瘤学会（SFRO）。由Elsevier Masson SAS出版。All rights reserved.
"Dose-painting" radiotherapy allows for a heterogeneous delivery of radiation within the tumour volume by targeting radioresistant areas defined by functional imaging. Within gross tumour volume, it is possible to define one or more target volumes based on biology (biological target volume [BTV]) and to apply a strategy of intensity modulated radiation therapy (IMRT) that will deliver a higher dose to these regions. In this review of the literature, we will highlight the biological elements responsible for radioresistance, and how to image them, then we will detail the radiotherapy techniques necessary for this approach, before presenting clinical results in various situations (head and neck tumours, prostate, brain tumours, etc.). Despite many difficulties that make dose-painting IMRT unusable in routine nowadays, biology-guided radiation therapy represents one of the major pathways of development of radiotherapy in the coming years. (C) 2010 Societe francaise de radiotherapie oncologique (SFRO). Published by Elsevier Masson SAS. All rights reserved.