A GOLGI-STUDY OF MOUSE HIPPOCAMPAL CA1 PYRAMIDAL NEURONS FOLLOWING PERINATAL ETHANOL EXPOSURE
A GOLGI-STUDY OF MOUSE HIPPOCAMPAL CA1 PYRAMIDAL NEURONS FOLLOWING PERINATAL ETHANOL EXPOSURE
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DOI：
10.1016/0304-3940(81)90424-9
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发表时间：
1981-01-01
影响因子：
2.5
通讯作者：
SMITH, DE
中科院分区：
文献类型：
--
作者：
DAVIES, DL;SMITH, DE
在围产期暴露于乙醇后的14日龄小鼠中检测了高尔基浸渍的海马锥体细胞。酒精损伤的时间与出生和树突发育的初始阶段一致，并通过在妊娠后期和产后第一周给母鼠喂食乙醇产生。高尔基浸渍细胞的定性和定量评估显示，乙醇暴露的动物基底树突的范围明显减少，这表明神经元发育延迟。
Golgi-impregnated hippocampal pyramidal cells were examined in 14-day-old mice following perinatal exposure to ethanol. The alcoholic insult was timed to coincide with the birth and initial stage of dendrite elaboration and was produced by dietary administration of ethanol to maternal mice during late pregnancy and the 1st postpartum wk. Qualitative and quantitative evaluation of Golgi-impregnated cells revealed a marked reduction in the extent of basilar dendrites in ethanol-exposed animals which suggested a delay in neuronal development.