The Frequency of anti-CCP antibodies in patients with rheumatoid arthritis and psoriatic arthritis and their relationship with clinical features and parameters of angiogenesis: A comparative study
The Frequency of anti-CCP antibodies in patients with rheumatoid arthritis and psoriatic arthritis and their relationship with clinical features and parameters of angiogenesis: A comparative study
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DOI：
10.5152/eurjrheumatol.2014.022
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发表时间：
2014-06-01
影响因子：
1.9
通讯作者：
Cakir, Necati
中科院分区：
文献类型：
--
作者：
Eker, Yeliz Ozkaya;Pamuk, Omer Nuri;Cakir, Necati
目的：评估巨噬细胞迁移抑制因子（MIF）和血管内皮生长因子（VEGF）作为血管生成和炎症的关键参数，以确定环瓜氨酸肽抗体（anti-CCP）在类风湿关节炎（RA）和银屑病关节炎（PsA）血管生成中的作用。材料与方法：本研究共纳入145例RA患者、44例PsA患者和73名健康受试者。记录RA和PsA患者的临床特征、总血细胞计数及急性期参数。采用酶联免疫吸附试验（ELISA）检测抗ccp抗体、VEGF和MIF水平。结果：RA组抗ccp阳性率（69%）明显高于PsA组（20.6%）和对照组（8.2%）（p值0.05）。VEGF和MIF水平在抗ccp阳性和阴性RA患者中相似（p值均为0.05）。抗ccp抗体对RA的特异性为87.2%。抗ccp抗体阳性与临床特征、疾病活动性、健康评估问卷评分评定的功能残疾和关节外表现无关系。血管生成参数与抗ccp抗体阳性无相关性。在大多数RA患者中，RF和抗ccp抗体均呈阳性。结论：RF或抗ccp抗体在相当比例的RA患者中呈阳性。因此，抗ccp抗体在有RA临床表现的rf阴性患者的诊断中具有重要意义。
Objective: Macrophage migration inhibitory factor (MIF) and vascular endothelial growth factor (VEGF), as crucial parameters of angiogenesis and inflammation, were evaluated to identify the role of cyclic citrullinated peptide antibodies (anti-CCP) during angiogenesis in rheumatoid arthritis (RA) and psoriatic arthritis (PsA).Material and Methods: A total of 145 patients with RA, 44 patients with PsA, and 73 healthy subjects were included in this study. The clinical features, total blood counts, and acute phase parameters of RA and PsA patients were recorded. Anti-CCP antibody, VEGF, and MIF levels were determined with enzyme-linked immunosorbent assay (ELISA).Results: Anti-CCP positivity was significantly higher in the RA group (69%) than in both PsA (20.6%) and controls (8.2%) (p values0.05). VEGF and MIF levels were similar in anti-CCP-positive and-negative RA patients (all p values>0.05). The specificity of anti-CCP antibodies for RA was found to be 87.2%. No relationship was found between anti-CCP antibody positivity and clinical features, disease activity, functional disability as assessed by health assessment questionnaire scores, and extra-articular manifestations. There was no relationship between parameters of angiogenesis and anti-CCP antibody positivity. Both RF and anti-CCP antibodies were observed to be positive in most patients with RA.Conclusion: Either RF or anti-CCP antibody was positive in a considerable proportion of our RA patients. Therefore, anti-CCP antibodies are important in the diagnosis of RF-negative patients who present with clinical findings of RA.