Extended high frequency audiometry in polycystic ovary syndrome.
Extended high frequency audiometry in polycystic ovary syndrome.
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DOI：
10.1155/2013/482689
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发表时间：
2013
影响因子：
--
通讯作者：
Oghan F
中科院分区：
文献类型：
--
作者：
Kucur C;Kucur SK;Gozukara I;Seven A;Yuksel KB;Keskin N;Oghan F
Objective.多囊卵巢综合征（PCOS）是最常见的内分泌疾病，影响5-10%的育龄妇女。胰岛素抵抗、血脂异常、糖耐量异常、高血压和肥胖是伴随该综合征的代谢紊乱。多囊卵巢综合征是一种慢性促炎状态，该疾病与内皮功能障碍有关。在内皮损伤的疾病中，高频听力大多在早期阶段受到影响。我们评估了PCOS患者的扩展高频听力损失。材料方法。40名被诊断为PCOS的妇女和25名健康对照者被纳入本研究。PCOS组和对照组的年龄和BMI相似。每名受试者都接受了低频（250-2000 Hz）、高频（4000-8000 Hz）和扩展高频（8000-20000 Hz）测听。计算激素和生化值，包括LH、LH/FSH、睾酮、空腹血糖、空腹胰岛素、HOMA-I和CRP。 结果PCOS患者的LH、LH/FSH、睾酮、空腹胰岛素、血糖、HOMA-I和CRP水平较高。在250、500、1000、2000和4000 Hz频率下，各组的听阈相似; PCOS组与对照组相比，在8000-14000 Hz频率下观察到统计学显著差异。结论PCOS患者有听力障碍，特别是在扩展的高频。需要进一步的研究来帮助阐明与PCOS相关的听力障碍背后的机制。
Objective. Polycystic ovarian syndrome (PCOS) is the most common endocrine disorder affecting 5–10% of women in reproductive age. Insulin resistance, dyslipidemia, glucose intolerance, hypertension, and obesity are metabolic disorders accompanying the syndrome. PCOS is a chronic proinflammatory state and the disease is associated with endothelial dysfunction. In diseases with endothelial damage, hearing in high frequencies are mostly effected in early stages. We evaluated extended high frequency hearing loss in PCOS patients. Material Methods. Forty women diagnosed as PCOS and 25 healthy controls were included in this study. Age and BMI of PCOS and control groups were comparable. Each subject was tested with low (250–2000 Hz), high (4000–8000 Hz), and extended high frequency audiometry (8000–20000). Hormonal and biochemical values including LH, LH/FSH, testosterone, fasting glucose, fasting insulin, HOMA-I, and CRP were calculated. Results. PCOS patients showed high levels of LH, LH/FSH, testosterone, fasting insulin, glucose, HOMA-I, and CRP levels. The hearing thresholds of the groups were similar at frequencies of 250, 500, 1000, 2000, and 4000 Hz; statistically significant difference was observed in 8000–14000 Hz in PCOS group compared to control group. Conclusion. PCOS patients have hearing impairment especially in extended high frequencies. Further studies are needed to help elucidate the mechanism behind hearing impairment in association with PCOS.