DNMT3A-Mutant Leukemia Cells Primed to "Fork It Over" under DNA Damage.
DNMT3A-Mutant Leukemia Cells Primed to "Fork It Over" under DNA Damage.
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DNMT3A 突变白血病细胞在 DNA 损伤下准备“分叉”。
DOI：
10.1158/1078-0432.ccr-21-3949
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发表时间：
2022
期刊：
影响因子：
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通讯作者：
Viny,AaronD
中科院分区：
文献类型：
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作者：
Viny,AaronD
基因DNMT3A中的突变已经在各种造血疾病中被鉴定，包括克隆性造血、骨髓增生异常综合征和急性髓性白血病。这种早期突变的临床意义和由此产生的增强的克隆适应性一直是治疗干预的焦点。第756页
Mutations in the gene DNMT3A have been identified in various hematopoietic conditions, including clonal hematopoiesis, myelodysplastic syndrome, and acute myeloid leukemia. The clinical significance of this early mutation and the resultant enhanced clonal fitness have been a focus for therapeutic intervention.See related article by Venugopal et al., p. 756