Fumonisin B1 as a Urinary Biomarker of Exposure in a Maize Intervention Study Among South African Subsistence Farmers
Fumonisin B1 as a Urinary Biomarker of Exposure in a Maize Intervention Study Among South African Subsistence Farmers
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DOI：
10.1158/1055-9965.epi-10-1002
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发表时间：
2011-03-01
影响因子：
3.8
通讯作者：
Gong, Yun Yun
中科院分区：
文献类型：
--
作者：
van der Westhuizen, Liana;Shephard, Gordon S.;Gong, Yun Yun
背景：食用被致癌伏马菌素高度污染的玉米与高食管癌发病率有关。本研究的目的是验证尿伏马菌素B-1（UFB 1）的生物标志物作为伏马菌素暴露的措施，并探讨减少暴露后，一个简单的和文化上可接受的intervention.Methods：在基线本土种植的玉米，玉米为基础的粥，和第一次排尿尿样收集女性参与者（n = 22），他们的传统食品的做法，在南非森塔内。在干预过程中，参与者接受了识别和清除明显感染的玉米粒以及清洗剩余玉米粒的培训。在为期两天的干预中，参与者每天都食用由分拣和清洗的玉米制成的粥。结果：在基线和干预后，基于粥（干重）消耗量的FB 1暴露的几何平均值（95%置信区间）分别为4.84（2.87-8.14）和1.87（1.40-2.51）mg FB 1/kg体重/天，（减少62%，P < 0.05）。UFB 1C，UFB 1肌酐标准化，从基线时的470（295-750）降至干预后的279（202-386）pg/mg肌酐（降低41%，P = 0.06）。UFB 1C生物标志物与FB 1摄入量在个体水平上呈正相关（r = 0.4972，P < 0.01）。FB 1的尿排泄量估计为FB 1摄入量的0.075%（0.054%-0.104%）。结论：UFB 1反映了个体FB 1暴露，因此代表了未来伏马菌素风险评估的一个有价值的生物标志物。影响：简单的干预方法，手分类和洗涤，可以积极影响暴露于伏马菌素的社区的食品安全和健康。癌症流行病学生物标志物Prev; 20（3）; 483-9。（C）2011年《非洲标准化评论》。
Background: The consumption of maize highly contaminated with carcinogenic fumonisins has been linked to high oesophageal cancer rates. The aim of this study was to validate a urinary fumonisin B-1 (UFB1) biomarker as a measure of fumonisin exposure and to investigate the reduction in exposure following a simple and culturally acceptable intervention.Methods: At baseline home-grown maize, maize-based porridge, and first-void urine samples were collected from female participants (n = 22), following their traditional food practices in Centane, South Africa. During intervention the participants were trained to recognize and remove visibly infected kernels, and to wash the remaining kernels. Participants consumed the porridge prepared from the sorted and washed maize on each day of the two-day intervention. Porridge, maize, and urine samples were collected for FB1 analyses.Results: The geometric mean (95% confidence interval) for FB1 exposure based on porridge (dry weight) consumption at baseline and following intervention was 4.84 (2.87-8.14) and 1.87 (1.40-2.51) mg FB1/kg body weight/day, respectively, (62% reduction, P < 0.05). UFB1C, UFB1 normalized for creatinine, was reduced from 470 (295-750) at baseline to 279 (202-386) pg/mg creatinine following intervention (41% reduction, P = 0.06). The UFB1C biomarker was positively correlated with FB1 intake at the individual level (r - 0.4972, P < 0.01). Urinary excretion of FB1 was estimated to be 0.075% (0.054%-0.104%) of the FB1 intake.Conclusion: UFB1 reflects individual FB1 exposure and thus represents a valuable biomarker for future fumonisin risk assessment.Impact: The simple intervention method, hand sorting and washing, could positively impact on food safety and health in communities exposed to fumonisins. Cancer Epidemiol Biomarkers Prev; 20(3); 483-9. (C)2011 AACR.