Long-term maternal and subsequent pregnancy outcomes 5 years after hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome
Long-term maternal and subsequent pregnancy outcomes 5 years after hemolysis, elevated liver enzymes, and low platelets (HELLP) syndrome
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DOI：
10.1016/j.ajog.2009.06.033
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发表时间：
2009-10-01
影响因子：
9.8
通讯作者：
Sibai, Baha
中科院分区：
文献类型：
--
作者：
Habli, Mounira;Eftekhari, Nahid;Sibai, Baha
目的：为了评估随后的妊娠结局和HELLP发病时的胎龄对HELLP后长期预后的影响，平均随访5年。研究设计：128例有HELLP病史的患者填写问卷并发送病历。溶血，肝酶升高，低血小板数据分层根据胎龄在发病HELLP 28 weeks.RESULTS：53例患者随后怀孕并发HELLP和先兆子痫24%和28%。在随访期间，33%的患者新发高血压，32%的患者抑郁，26%的患者焦虑，2.4%的患者需要透析。有比较groups.CONCLUSION：有HELLP病史的患者是在子痫前期和HELLP以及长期发病率为抑郁症和慢性高血压的风险增加的长期结果之间没有显着差异。HELLP发病时的年龄可能是长期预后的预测因素。
OBJECTIVE: To evaluate subsequent pregnancy outcome and impact of gestational age at onset of HELLP on long-term prognosis after HELLP over an average follow-up of 5 yearsSTUDY DESIGN: One hundred twenty-eight patients with a history of HELLP filled out questionnaires and sent their medical records. Hemolysis, elevated liver enzymes, and low platelets data were stratified according to gestational age at onset of HELLP 28 weeks.RESULTS: Fifty-three patients had subsequent pregnancies with 24% complicated by HELLP and 28% by preeclampsia. During follow-up, 33% of the patients had new onset hypertension develop, 32% had depression develop, 26% had anxiety develop, and 2.4% required dialysis. There was no significant difference in long-term outcome between comparison groups.CONCLUSION: Patients with a history of HELLP are at increased risk for preeclampsia and HELLP as well as long-term morbidities as depression and chronic hypertension. Gestational age at the onset of HELLP could be a predictor for long-term outcome.